Guide for the Care and Use of Laboratory Animals (1996) / Chapter Skim
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1 Institutional Policies and Responsibilities
1 Institutional Policies and Responsibilities
Pages 8-20
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From page 8... ...
At least one veterinarian qualified through experience or training in laboratory animal science and medicine or in the species being used must be associated with the program. The institution is responsible for maintaining records of the activities of the IACUC and for conducting an occupational health and safety program.
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From page 9... ...
Committee membership should include the following: · A doctor of veterinary medicine, who is certified (see American College of Laboratory Animal Medicine, ACLAM, Appendix B) or has training or experience in laboratory animal science and medicine or in the use of the species in question.
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From page 10... ...
Such procedures might include physical restraint, multiple major survival surgery, food or fluid restriction, use of adjuvants, use of death as an end point, use of noxious stimuli, skin or corneal irritancy testing, allowance of excessive tumor burden, intracardiac or orbital-sinus blood sampling, or the use of abnormal environmental conditions. Relevant objective information regarding the procedures and the purpose of the study should be sought from the literature, veterinarians, investigators, and others knowledgeable about the effects on animals.
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From page 11... ...
Less-restrictive systems that do not limit an animal's ability to make normal postural adjustments, such as the tether system for nonhuman primates and stanchions for farm animals, should be used when compatible with protocol objectives (Bryant 1980; Byrd 1979; Grandin 1991; McNamee and others 1984; Morton and others 1987; Wakeley and others 1974~. When restraint devices are used, they should be specifically designed to accomplish research goals that are impossible or impractical to accomplish by other means or to prevent injury to animals or personnel.
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From page 12... ...
If multiple major survival surgery is approved, the IACUC should pay particular attention to animal well-being through continuing evaluation of outcomes. Cost savings alone is not an adequate reason for performing multiple major survival surgical procedures (AWRs)
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From page 13... ...
, and the institution should provide for formal or on-thejob training to facilitate effective implementation of the program and humane care and use of animals. According to the programmatic scope, personnel will be required with expertise in other disciplines, such as animal husbandry, administration, laboratory animal medicine and pathology, occupational health and safety, behavioral management, genetic management, and various other aspects of research support.
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From page 14... ...
The extent and level of participation of personnel in the occupational health and safety program should be based on the hazards posed by the animals and materials used; on the exposure intensity, duration, and frequency; on the susceptibility of the personnel; and on the history of occupational illness and injury in the particular workplace (Clark 19933.
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From page 15... ...
Facilities, Procedures, and Monitoring Facilities required to support occupational health and safety concerns associated with animal care and use programs will vary. Because a high standard of personal cleanliness is essential, facilities and supplies for meeting this obligation should be provided.
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From page 16... ...
Special facilities and safety equipment are needed to protect the animal-care and investigative staff, other occupants of the facility, the public, animals, and the environment from exposure to hazardous biologic, chemical, and physical agents used in animal experimentation. Facilities used for animal experimentation with hazardous agents should be separated from other animal housing and support areas, research and clinical laboratories, and patient-care facilities and should be appropriately identified; and access to them should be limited to authorized personnel.
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From page 17... ...
Protective clothing and equipment should not be worn beyond the boundary of the hazardous-agent work area or the animal facility. Personnel with potential exposure to hazardous agents should be provided with personal protective equipment appropriate to the agents (CFR 1984c)
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From page 18... ...
Animal technicians, clinicians, investigators, predoctoral and postdoctoral trainees, research technicians, consultants, maintenance workers, security personnel, and others who have contact with nonhuman primates or have duties in nonhuman-primate housing areas should be routinely screened for tuberculosis. Because of the potential for Cercopithecine herpesvirus 1 (formerly Herpesvirus simiae)
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From page 19... ...
Occupational Health and Safety in the Care and Use of Research Animals. A report of the Institute of Lab<'rat<'ry Animal Resources Committee on Occupational Safety and Health in Research Animal Facilities.
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From page 20... ...
1996. Public Health Service Policy on Humane Care and Use of Laboratory Animals.
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