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Appendix B: Agents with Potential Carcinogenic Activity and Their Occurrence...
Pages 377-406

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Select key terms on the right to highlight them within pages of the chapter.


From page 377...
... evidence in animals, without other highly suggestive ciata from human or mechanistic studies woulct not result in a 2B rating. The committee relied on lARC and NTP classifications of potential carcinogens as a means of obtaining a large set of agents of potential concern that have been systematically and rigorously evaluated by the same criteria.
From page 378...
... Thus, parallel problems ar encountered with drug residues and with pesticide residues as well. The number of all these is large, and establishing exposure with any accuracy to a quantitatively minor substance in our complex food supply entails major problems of surveillance, sampling, and analy sts.
From page 379...
... to dose response data from animal cancer bioassays, thereby providing a lower confidence limit on the TDo~. This pro cedure inctucled corrections for differences in pharmacokinetics at high and low doses, study length, and animal body size.
From page 380...
... Where there were multiple studies of similar quality conducted in the most sensitive species, the geometric mean of potencies cle rived from these studies was calculated. When both sexes of the same species/strain were tested under the same laboratory conch lions, and no other adequate studies were available for that species, the data set for the more sensitive sex was selected.
From page 382...
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From page 383...
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From page 384...
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From page 386...
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From page 387...
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From page 391...
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From page 396...
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From page 398...
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From page 400...
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From page 401...
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From page 402...
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From page 403...
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From page 405...
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From page 406...
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