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Regulating Pesticides (1980) / Chapter Skim
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Appendix C: Estimates of the Carcinogenicity of Chlorobenzilate
Pages 258-261

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From page 258...
... Since this estimate was derived from a test group numbering only 17, it is subject to a substantial sampling error. In this appendix the 90 percent confidence interval for the excess probability of hepatomas will be derived and will be used to compute the 90 percent confidence interval for the CAT for chlorobenzilate.
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From page 259...
... = Pc + (1 - Pc) Px, where Px is the unknown excess probability of incidence in the test animals.
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From page 260...
... The calculation of the dose is as follows: Daily ration Concentration of chlorobenzilate Daily intake of chlorobenzilate Duration of test Total intake of chlorobenzilate Molecular weight of chlorobenzilate Total intake in m moles Weight of animal Dose in m moles per kg per lifetime 5g 603 ppm 3.015 mg 575 days 1733 mg 325.2 5.33 0.030 kg 178
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From page 261...
... Memorandum to Joe Boyd, Project Manager, Special Pesticide Review Division, Office of Pesticide Programs, dated August 18, 1978. CAG, Office of Research and Development, U.S.
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Key Terms

  • percent confidence
  • excess probability
  • test animals
  • maximum likelihood
  • confidence limit

  • total intake
  • male strain
  • lifetime intake
  • upper confidence
  • dated august

  • final risk
  • pesticide review
  • chlorobenzilate duration
  • strain x
  • daily intake

  • daily ration
  • chlorobenzilate total
  • review division
  • x mice
  • test total

  • easily seen
  • joe boyd
  • ration concentration
  • molecular weight
  • cag final

  • lower confidence
  • unknown excess
  • moles weight
  • dose equals
  • equals lifetime


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