Biographical Memoirs Volume 70 (1996) / Chapter Skim
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Choh Hao Li
Choh Hao Li
Pages 220-239
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Li was a pioneer in the synthesis of biologically active pepticles en c! proteins and analogs of the natural species and accomplished the chemical synthesis of melanotropins, corticotropins, enclorphins, lipotropin, en c!
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Plaque of Honor for Achievement in Chemistry, CzechosIovak Academy of Sciences. His major American awards are the Lasker Award, the Lewis Prize of the American Philosophical Society, en c!
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H stopped in Berkeley to visit his brother, a graduate student in business administration, Choh Ming acivisec!
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Amino acid analysis, amino acid sequencing, en c! X-ray crystallography were only cireams, en c!
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of promising experiments on the determination of amino acid sequences in insulin, and so he changed his plans to spend a month with Fret! Sanger en c!
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I clearly recall nervously taking my turn, chatting over a cup of especially clelicious jasmine tea, en c! then presenting my most exciting recent finclings.
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for a while in the lab. Li macle a point of generously sharing the time of the famous ones with all of us, it was a heacly experience for a graduate student.
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the spoiling of the starting material as an excuse for failing to purify corticotropin before the others. In 1955 the amino acid sequence of corticotropin was publisher!
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H was that biologically active fragments conic!
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The experience gainer! in synthesis of ACTH was valuable in subsequent syntheses of other protein hormones lipotropin, endorphin, and a growth hormone.
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to play a role as research on lipotropin progressed. When the amino acid sequence of lipotropin was clecipherec!
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. covered the extensive comparisons of amino acid sequences in most of these hormones across a very wide range of animal species, comparisons that were a rich source of data on evolution, and on structure/function relationships.
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There was another of those sicle products that Li was alert enough to purify, characterize by amino acid sequence, and synthesize. Perhaps C
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that the stock of the companies producing it by genetically engineered processes hac! risen abruptly.
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of spirit among those who worker! in the Hormone Research Lab at one time or another.
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:33352~. Other information came from two books edited by Li entitled Hormone Research Laboratory 1950-1970 and Hormone Research Laboratory 1950-1980, which were published as limited editions by the University of California Press to commemorate the twentieth and thirtieth anniversaries, respectively, of the founding of the laboratory.
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Barnafi. The isolation, characterization and amino-acid sequence of a melanocyte-stimulating hormone from bovine pituitary glands.
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Sequence comparison of human pituitary growth hormone, human chorionic somatomammotropin and ovine pituitary lactogenic hormone. Experientia 27: 1368-71.
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p-Endorphin: Intravenous infusion causes behavioral change in psychiatric inpatients.
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