Biographical Memoirs Volume 70 (1996) / Chapter Skim
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Herschel L. Roman
Herschel L. Roman
Pages 348-367
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From page 349... ...
Mecial, Christian Hansen Foundation, Copenhagen, Thomas Hunt Morgan Mecial, Genetics Society of America, honorary doctorate, University of Paris, Doctor of Science, honoris cause, University of Missouri-Columbia, and presi 349
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From page 350... ...
Committee, member of the NSF Genetic Biology Panel, en c! consultant to the Biology Division of Oak Ridge National Laboratory, Hersch fosterec!
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From page 351... ...
This funciamental observation suggestec! that one might obtain information about the chemical composition of the gene by determining the action spectrum of ultraviolet light mutagenesis.
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From page 352... ...
strains containing one or two B-type chromosomes suggester! that mitotic nonclisjunction of B-type chromosomes occurs at high frequency cluring one or both of the postmelotic mitotic divisions that comprise pollen grain formation in maize.
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From page 353... ...
the plant zygote containing two B-type chromosomes. Mitotic nondisjunction of B-type chromosomes cluring pollen grain clevelopment couplet!
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From page 354... ...
To take advantage of the growing power of microbial genetics he chose the budding yeast Saccharomyces cerevisiae because of its unicellular character,
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From page 355... ...
the initial yeast genetics team at Seattle. While Hersch's principal research interests were in the areas of gene mutation, chromosome behavior en c!
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From page 356... ...
pigment due to the block in adenine biosynthesis and form red colonies on nutrient meclium. in contrast to all other yeast strains which form white colonies.
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From page 357... ...
following meiosis proviclec! inclisputable evidence that intragenic recombination occurs principally by non-reciprocal recombination.
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From page 358... ...
homoallelic cliploicis. Following meiosis, heteroallelic diploids typically yielded Ade+ prototrophs at frequencies ten to a thousanc!
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From page 359... ...
During meiosis of yeast non-reciprocal recombination between heteroalleles occurs in frequent non-ranclom association with orthodox reciprocal recombination of heterozygous markers flanking the heteroallelic locus. During mitosis non-reciprocal recombination between heteroalleles also occurs in non-ranclom association with orthodox reciprocal recombination of heterozygous markers flanking the heteroallelic locus, however, in mitotic cells the extent of nonranclom association is typically less than in meiosis.
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From page 360... ...
that gene conversion en c! reciprocal recombination of heterozygous markers flanking the site of gene conversion are separable events.
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From page 361... ...
It was possible to account for the simultaneous occurrences of G] mitotic gene conversion and reciprocal recombination of flanking heterozygous markers by replicational resolution of Holliciay structures, as occurs in some bacteriophages.
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From page 362... ...
recombination, although the vast majority of melotic gene conversions and reciprocal recombination occur later during the prophase stage of melotic G2 cells, thus, the different properties of mitotic and meiotic recombination could be explained if G] events play a major role in mitosis and a minor role in meiosis, while G2 events play a minor role in mitosis and a major role in · ~ melosls.
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From page 363... ...
The welfare of the genetics graduate students at Seattle was Herschel's prime concern, we were his academic family. On social occasions Hersch, his wife CaryT, en c!
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From page 364... ...
Anderson, 1946-48 Guggenheim Fellow, University of Paris, host: Boris Ephrussi, 1952 Fulbright Research Scholar, University of Paris, host: Boris Ephrussi, 1956 President, International Congress of Yeast Genetics and Molecular Biology, 1961-84 President, Genetics Society of America, 1968 Elected to the American Academy of Arts and Sciences, 1969 Elected to the National Academy of Sciences, 1970 Citation of Merit, University of Missouri-Columbia, 1973 Gold Medal, Emil Christian Hansen Foundation, Copenhagen, 1980 Thomas Hunt Morgan Medal, Genetics Society of America, 1985 Honorary doctorate, Universite Pierre et Marie Curie, Paris, 1986 Doctor of Science, Honoris cause, University of Missouri Columbia, 1989
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From page 365... ...
34:36-42. 1950 Factors affecting mitotic nondisjunction in maize.
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From page 366... ...
5:35-48. 1976 Recombination in Saccharomyces cerevisiae: a DNA repair mutation associated with elevated mitotic gene conversion.
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From page 367... ...
80:6912-16. 1984 A comparison of induced and spontaneous gene conversion in mitotic and meiotic cells of Saccharomyces cerevisiae.
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