Resource Sharing in Biomedical Research (1996) / Chapter Skim
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3: THE MULTINATIONAL COORDINATED ARABIDOPSIS THALIANA GENOME RESEARCH PROJECT
3: THE MULTINATIONAL COORDINATED ARABIDOPSIS THALIANA GENOME RESEARCH PROJECT
Pages 33-38
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From page 33... ...
The resulting project plan called for genetic and physiologic experiments to identify, isolate, sequence, and understand genes; the establishment of worldwide electronic communication among laboratories; the establishment of resource centers for collection and dissemination of genetic stocks, genes, and related materials; and the creation of databases so that new knowledge would be shared. The project plan also contained mechanisms for formal, annual progress reviews and periodic establishment of new goals by a multinational steering committee 33
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From page 34... ...
Ongoing communications among scientific administrators, the scientific community, and the national and international steering committees facilitate the identification of needs, rationalization and prioritization, and negotiations with agencies around resource requirements. The remarkable collaborative spirit of the participants has made it a successful model for scientific cooperation among several thousand participating scientists and scientific administrators in Asia, Australia, Europe, the Middle East, and the Americas.
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From page 35... ...
, wield considerable influence in this respect, as do the heads of the major laboratories, who have encouraged openness and sharing by clear public acknowledgments to depositors of data and materials. Although at this time the Arabidopsis community requires that genome sequences be deposited in the public database three months after they are publicly available, the multinational steering committee is considering requesting that journals publishing in this area require an accession number from the stock centers indicating that experimental materials have been deposited.
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From page 36... ...
Enforcement is more complicated at the international level. The international steering committee is trying to negotiate the contribution of a collection of mutants made by a consortium in Europe, where strong pressure is being put on scientists by their funding agencies to limit distribution to those willing to cede or share future commercial benefits.
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From page 37... ...
OTHER ISSUES AND PROBLEMS In his presentation at the workshop, Chris Somerville of Stanford and the Carnegie Institution, one of the project's original organizers, identified factors that are instrumental in the sharing of resources. These include the leadership of program managers in government agencies that support the research; the leadership and example of senior scientists and prominent laboratories; an oversight committee with broad representation of countries and scientists that sets policy, adjudicates problems, and can make proposals to Finding agencies based on the needs of the community; investment in infrastructure such as stock centers and information databases; support for workshops and other scientific meetings; and a process for annual updating of a plan.
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From page 38... ...
38 RESOURCE SHARING IN BIOMEDICAL RESEARCH as well as the ongoing administrative load imposed by the need for an active process of soliciting deposits, a time-consuming activity given the pace of research on Arabidopsis. More information on this case study is available from NSF in the project's progress report for year four.
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