Resource Sharing in Biomedical Research (1996) / Chapter Skim
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6: THE MACROMOLECULAR CRYSTALLOGRAPHY RESOURCE AT THE CORNELL HIGH ENERGY SYNCHROTRON SOURCE
6: THE MACROMOLECULAR CRYSTALLOGRAPHY RESOURCE AT THE CORNELL HIGH ENERGY SYNCHROTRON SOURCE
Pages 53-60
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From page 53... ...
The larger community must support the construction of the synchrotron storage rings (which cost several hundred million dollars) , while smaller groups of researchers band together in order to instrument individual beam lines for specific types of experiments.
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From page 54... ...
Core Research Projects Core research projects are performed by MacCHESS faculty and staff and are intended to advance the capabilities of the research resource. Core research projects provide the driving force for new developments such as advanced xray detectors, cryo-crystallography apparatus, new beam line optics, new x-ray instrumentation, and new data analysis software.
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From page 55... ...
Training and Dissemination Workshops and Symposia As a user facility, MacCHESS provides visiting scientists with on-site training for all aspects of macromolecular crystallography including crystal freezing, experimental design, operation of station bench cameras, use of both image plate scanners and charge-coupled device (CCD) -based x-ray detectors, and evaluation and processing of data using various processing programs.
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From page 56... ...
The proposals are sent to external reviewers for evaluation, and a final priority score is assigned by a proposal evaluation committee comprised of scientists representing all major areas of synchrotron radiation research. Access to CHESS is based on scheduling requirements and the final priority score.
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From page 57... ...
However, since synchrotron time is even more limited than grant support, the issue of awarding time to an unfunded project appears to be rarely, if ever, faced. Some of the most active scientists using synchrotron time are peripatetic wanderers who submit multiple applications to multiple facilities and use time wherever and whenever it can be found.
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From page 58... ...
Cornell is the only synchrotron source funded by NSF and, thus has been affected only indirectly (changing demand for beam time) by these changes in DOE funding, but the dependence of the structural biology community upon support for a very high budget physics program is an obvious hazard in an era of tight money.
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From page 59... ...
Perhaps for this reason and because of the need to meet developmental timetables, a group called the Industrial Macromolecular Crystallography Association has raised enough money to build two beam lines at the advanced photon source about to open at Argonne National Laboratory. In return for "their own" beam lines, they have promised to give 25 percent of beam time to independent outside users.
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From page 60... ...
60 RESOURCE SHARING IN BIOMEDICAL RESEARCH danger in this model is possible stagnation in the continued development of novel capabilities for new science. Attention must be paid to a balance between these competing needs (a competition likely to be exacerbated in an era of restrained funding)
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