Resource Sharing in Biomedical Research (1996) / Chapter Skim
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7: THE HUMAN GENOME CENTER: LAWRENCE LIVERMORE NATIONAL LABORATORY
7: THE HUMAN GENOME CENTER: LAWRENCE LIVERMORE NATIONAL LABORATORY
Pages 61-70
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From page 61... ...
The resources shared by Livermore fall into several categories described below. LAWRENCE LIVERMORE NATIONAL LABORATORY Lawrence Livermore National Laboratory (LLNL)
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From page 62... ...
The LLNL Human Genome Center is the focus of this activity. HUMAN GENOME CENTER DOE has established genome centers at three sites, Los Alamos National Laboratory (LANL)
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From page 63... ...
The following sections describe the center's experiences in attempting to share locally developed instrumentation and technology, information, and biological materials with the wider scientific community. Instrumentation and Technology Instrumentation and technology is the area in which LLNL and center policies and experiences have been most conventional and most "successful." Instrumentation with commercial potential is basically kept proprietary until an invention disclosure or patent application is filed.
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From page 64... ...
The Human Genome Project is dependent upon, and therefore insists upon, sharing however, and the LLNL center's general rules call for holding unconfirmed data private until verified, but for no more than six months. Some exceptions
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From page 65... ...
Livermore's initial involvement in the Human Genome Project was a joint effort with Los Alamos National Laboratory called the National Laboratory Gene Library Project, a task now essentially complete. All the libraries were made.
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From page 66... ...
receive no monetary remuneration for the clones or the libraries that go to ATCC. Cosmid libraries are a little more difficult; so Livermore and Los Alamos basically split the 24 chromosomes present in the human genome.
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From page 67... ...
However, only two responses were received from for-profit companies in this country, and neither was willing to meet the requirements of the qualifiers. Chromosome 19-Specific Cosmids The Human Genome Center at LLNL has a very high resolution metric map of cosmids that spans nearly the entire chromosome 19.
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From page 68... ...
Solicitation through Commerce Business Daily was more successful in this case however, and there are now several distribution centers, including ATCC, from which interested laboratories can obtain clones. OWNERSHIP AND ACCESS ISSUES The Human Genome Center has responded to the exponential growth in requests for information and material resources by developing explicit guidelines and agreement forms, the essence of which has been conveyed above, but they will be summarized here for convenience.
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From page 69... ...
Another not infrequent problem is that multiple investigators utilizing the resources of the Human Genome Center, (i.e., sharing those resources) are not willing to share with each other, even when another (competitive)
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