Skip to main content

Currently Skimming:

4: STRATEGY FOR IDENTIFYING AND DEALING WITH INTERACTIONS
Pages 34-51

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 34...
... Because of this it is not feasible to predict and eliminate all potentially adverse interactions. Therefore, the committee urges that studies be focused on those interactions that are likely to occur, that may compromise military unit or individual effectiveness, or, although rare, that may cause severe consequences.
From page 35...
... TABLE 4-1 Categorical Approach Interaction Type Recommended Approaches Known Potential Unknown · Avoid unless benefit outweighs risk · Use surveillance to monitor outcomes and implement appropriate intervention · Study in depth · Use matrix approach to predict or identify the interaction · Conduct studies (in vitro, animal, or human volunteer) · Use surveillance · Put in place surveillance systems to detect sentinel events and do follow-up studies Do prospective screening studies of important combinations
From page 36...
... The matrix approach described in this chapter would serve as a screening step. Determining that toxic interactions between combinations of agents actually occur requires appropriate in vitro, animal toxicity, human volunteer, or epidemiologic studies for validation.
From page 37...
... Finally, although epidemiologic studies are more likely to involve exposures of humans to mixtures of chemicals or other toxic agents and could thus provide a more reliable basis for risk assessment than toxicologic studies with animals, epidemiologic data are rarely available for the specific mixtures of agents and exposure situations of interest. Thus, the committee proposes an additional series of prospective animal toxicity studies (Chapter 51.
From page 39...
... 39 As By o ·- o =^ to A)
From page 45...
... 45 no .= c)
From page 48...
... 48 s ·_ 6 Ed V' of ._ ._ ._ Cal o .' o so on ° ~ E £ of En a: "S: ._ .
From page 49...
... 49 at s: c)


This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
More information on Chapter Skim is available.