Biographical Memoirs Volume 71 (1997) / Chapter Skim
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BERNARD N. FIELDS
BERNARD N. FIELDS
Pages 63-78
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From page 63... ...
In particular, Bernie will be remembered for emphasizing the importance of basic research in the area of clinical medicine en c! in helping to clefine molecular parameters that affect disease.
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From page 64... ...
the history of the Chinese Revolution, Irving Howe taught English, en c! Max Lerner taught American Civilization.
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From page 65... ...
before starting his training in molecular biology, Bernie hac! to clo his military service, which he was able to clo at the Communicable Disease Center (now the Centers for Disease Control en c!
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From page 66... ...
to the Albert Einstein College of Medicine, where he began postcloctoral training with Bill Joklik. Joklik was well known for his work on vaccinia virus (perhaps this is one reason for Bernie's later interest in the smallpox virus)
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From page 67... ...
Reovirus particles contain ten different segments of RNA. Each segment cocles for a particular reovirus protein.
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From page 68... ...
Now directing his own lab, Bernie set out to determine whether these different phenotypes could be associated with a single gene en c! thus a single protein of reovirus.
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From page 69... ...
Because it seems to me that the students, who at any level often make the most profound discoveries, are talking from a very unique perspective, which is often their own metaphors, their own insights. The first thing that I like to find out is who the student is, where are they coming from, what they are excited about.
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From page 70... ...
There are genes that produce a protein that can interact with a major histocompatibility protein and thereby affect the immune response. The complexity of the smallpox genome almost certainly means that there will be genes in this virus that have important perhaps unique functions in causing disease.
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From page 71... ...
It was a very difficult experience because suddenly whatever future we all think we have was removed from me since cancer of the pancreas has a rather grim prognosis. In my own personal case, I was fortunate to go to a physician at the Dana Farber Bob Mayer who immediately changed my perspective and pointed out that I was a statistic of one, and even though I know the statistics of cancer of the pancreas, he said let's see what happens with you.
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From page 72... ...
I would never have thought five, six months ago that I would have had a productive and fun fall. I also wouldn't have thought that I would have been here and would have had a future.
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From page 73... ...
Fields, an oral history. This is an edited quote from the interview conducted by me on December 8, 1992.
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From page 74... ...
Absolute linkage of virulence with central nervous system cell tropism of reoviruses to viral hemagglutinin.
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From page 75... ...
Ammonium chloride prevents lytic growth of reovirus and helps to establish persistent infection in mouse L cells. Science 219:987-88.
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From page 76... ...
Ion channels induced in lipid bylayers by subvirion particles of the nonenveloped mammalian reoviruses.
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