Biographical Memoirs Volume 72 (1997) / Chapter Skim
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ROBERT BRAINARD COREY
ROBERT BRAINARD COREY
Pages 50-69
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From page 51... ...
configurations of amino acid arrangements in proteins of all types, his name survives as the first initial in the naming of the CPK moclels, which are still in extensive use. l PERSONAL HISTORY Sometime in his youth I clon't know when or why he was given the nickname "Jim", his wife en c!
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From page 52... ...
, were collaborating and constructing what undoubtedly was the first all-glass vacuum line, patterned after that initiated by Stock in Germany, in this country. Considering that only 'soft' glass was then available and interchangeable slip joints and stopcocks were unknown, and diffusion pumps had not yet been invented, this project was indeed heroic.
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From page 53... ...
Wyckoff were joint authors of eighteen papers describing diffraction studies on compounds ranging from organic chIorostannates to crystalline en c! fibrous proteins.
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From page 54... ...
that you bring with you apparatus of this type which you think is needed for your own work." Corey accepted the appointment, also by return mail, on May 8, 1937. He and his equipment arrived in Pasadena in September (that Weissenberg camera remainec!
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with strong supporting evidence supplied by Corey.
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From page 56... ...
to generate and separate GeH4, Ge2H6, and higher hydrides. The vacuum line contained, along with a dozen or so collection tubes, a mercury manometer and ten mercury valves Yshapec!
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From page 57... ...
There is certainly no indication of any similar damage to Bob Corey's intellect. Although Bob's initial faculty appointment at Cornell was in analytical chemistry, he quickly became attracted!
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From page 58... ...
For diketopiperazine the first model that Corey tested was based on a puckered six-membered ring, as in cyclohexane, only when that model failed was a planar ring tested and found to produce satisfactory agreement between measured and calculated diffraction intensities. While Pauline and perhaps others may already have sus a pected that the amide grouping in peptides would be pla nar (because of the double-bond character in the C-N bond)
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From page 59... ...
been thoroughly eclectic, embracing thermodynamics, quantum mechanics, gas-phase electron diffraction, en c! crystal structure studies of all kinds minerals, intermetallic compounds, en c!
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It is surely worth noting in passing that these seminal papers by Pauling and Corey were written in the most conservative of styles en c! backer!
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From page 61... ...
from "Tinker Toys," wooden balls en c! sticks representing atoms en c!
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From page 62... ...
at the warm reception he had received everywhere. In the late 1950s, with the structural features of fibrous proteins firmly in hancI, Corey focuses!
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From page 63... ...
that the lack of true isomorphism wouIc! make the resultant electron density maps unreliable.
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From page 64... ...
I am indebted to Ruth Hughes, Eddie's widow, for material he had collected; to the Caltech archives for letters, references, and the photograph of Corey; and to Ramesh Krishnamurthy, project director for the Ava Helen and Linus Pauling papers at Oregon State University, for early correspondence between Corey and Pauling. I am also indebted to Verner Schomaker for many helpful comments, ideas, and remembrances.
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From page 65... ...
However, Pauling's book also contains the curious statement, "There exist no data regarding the configuration and dimensions of the amide group." Probably Pauling believed that the constraints imposed by the cyclic nature of diketopiperazine ruled out its consideration as a legitimate amide.
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From page 66... ...
The crystal structure of trimethyl ethyl ammonium chlorostannate.
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From page 67... ...
Configurations of polypeptide chains with favored orientation around single bonds: Two new pleated sheets.
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From page 68... ...
An X-ray investigation of lysozyme chloride crystals containing complex ions of niobium and tantalum. Three-dimensional Fourier plot obtained from data extending to a minimum spacing of 5 A
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