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Evolution by the birth-and-death process in multigene families of the vertebrate immune system
Pages 109-116

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From page 109...
... To resold this controvert ~ conducted p~lo~netit analyses of seve~1 mulfigene families <>f the TIC Id ~ bosoms. Ibe Ensues sub that Abe ~ludon~ pattern of thee amides is quad dimwit ~ mat of concerted Mouton but is in ag~emen1~ file bir~-and-dea~ model of Solution in Ibid n~ genes are created by repented ante dupU~Hon and some ~pli~te gents are malutained in me gnome Air ~ long time but others are deleted or become non~nchonal ~ deleterious muttons.
From page 111...
... We Shave fierce construct~d~phylogenedc traces far human class ll~ and genes separately Fig. i shows 1hc Bee IF HISS 11 ~ Bcnes mom tbrcc polymorphic loci a.
From page 112...
... 4~. This indicates 1~1 far ~laliv~ly closed related o~n~ms brand loci maintain their Ninety identity despite ibe appoint ~cur~n~e of repeated gene dup~c~ion and that no or i:n~tcllocus~elletico=~han~es~haveocc~ul,qd~:mon~diEtIelltloc~i.
From page 113...
... C<~llogoTum lS>aper:~Nci~/.
From page 114...
... pigs, and rabbits, which arc all d<>m~stic~ted animals. Particularly in1oresdrg are the ca1Uc and sheep gene clusters Limb belong to group B
From page 115...
... However, heyhavenotdoncanys1~t~istic~IlestoF:ll~Je~l~icclusters,andit seemsthatthis iIllc~rnlin~ling of~llclosir<>m di~f~r~nllociwas causedbystocb~ticors~mpling~n~r~{course.therarea~ dcar-cutc~scsof~n ~hanyesb~t~cndib~rent~IlCloci (I3,66~.bu1theircontr~utionto M HC ~nc diverge scemsto \~(# BIrtb-and-Dealh ~odelofE\olulion.Inthismodelofevolu~ tiOll. d~lplical~gc~lesareprodtlced ~ variousmcc~hallisl~sill~ Eluding tandem and block gene duplication.
From page 116...
... This may fill be the cave, but chicken and r~i1 IN fines are clears ~eplional and do not seem to fallow Me Menorah pattern of Ig gene cvo~lutio~ in ve~r10br~t~s. be genomo of biker organisms contains a large number of ~ ~i~, ~ of #- ha gad ~ ~~ lard quanlity of the same gone product and others of which h~c Evolved to produce a diverse array of proteins.


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