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Long term trends in the evolution of H(3) HA1 human influenza type A
Pages 22-28

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From page 22...
... 0~) The ~placemen1 substi~Hons a~ distributed randomly across the thee posidod, of the codas when advance ~ made ~r 1be number of Is each codon can change the encoded amino acid.
From page 23...
... Thccomputerprogram numbersalllbenodosofthetrce, th~ Arst 2i4 ndmbers b~ing ~ivon to tbe tip nodestha rOprcsentthcorigin~lsequcncrsandthen~xt252numbers &0ingtoinlcriornodcsofJeprec3.nodes~bEthrc~branGbOs Q1tacb~d.E~rybr~ncb~6ol~eled,and1hatlabelh1bC same~sthelabelont~ nodetowhich~des~nds.lbus~c c~n un~mbiguous~ speak oftip branchesas weH ~sIlp nodes OSill~ thes:~menu~b~r. Wodefino SiStCF nodcsrestr~ict~ively10 be tbose pairs of dp scquenceslhaL t~poloyical>.
From page 24...
... 77T4 C~loqulum Paper: Ditch ~/ ~t c o ,_ .~ ~ 40 o ._ o o c = o o E e a a c .
From page 25...
... Thero ~re <\ h~ctvariable codons (138 14i 1 i6.
From page 27...
... While one normally thinks ofvariabla colons being those that gave al l~sstone~1t~rn~lL~ amino acidibatisnoldelclchous in His case abet ~ not n~cossarHy so because we could be seeing aber~ativ~sbc~re selection has6~credth~m out.Tbus1herc ~ nothing wrong ~itb there being extra changes on the tip branches nor thatlhere are many more vocable cations far ~em.l1Ere~sonablotoexpecl mom vahablccodonsif~o can .
From page 28...
... ~c gratefully acknowledge 1be technical expertise contributed by iguana jing and Donna Sasso Id soqu~ncos conldbut~d by Dc. Selsuto Nak~ima.


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