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(NAS Colloquium) Genetics and the Origin of Species From Darwin to Molecular Biology 60 Years After Dobzhansky (1997) / Chapter Skim
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Evolution of codon usage bias in Drosophila
Pages 94-100

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 94...
... He then examine possible causes of these put-ons and discount mut"-n bias on the bash: tow ~ Mile eid~ce of ~giona1 mutation bias In ~^ mutation bias Is likely toward A+1 Abe opposhe ofrodon usage blase and not~11 mInoacidsdispl~ytbepre~rence ~rthesumenu~leolidein the ~obbleposldon.1~ Unesofevidencesupportaselection hypotbesisbased ontR`A pools:biphly biased genestendfo behighlynnd/orrapidlyexpressed,andthepre~rredcodons in bigb~ biased genes optlmall~ bind 1be most abund~u1 isOnCceptingtR`As.FinnU>~eexaminetheentc10fbiason D\~tvo~utionandconOrm thafgenes~Hh bighrodonusage bias brave lower rates of synonymous substitution between speCiestbandogenes~Ubio~codonusagebl~s.Surprisingb. (nndthaf~enes~Ubblghercodonusageblasdispl~ybigher levelsoflntraspeclOcs~non~mous polymorphism.
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From page 95...
... e biasofa g~ne :~hd ~ifso,~l<~tll~y slls~ho~ tlle samc pat1:er~n {i.~., '~# in~ease in C cnding codonsj? Comp~ing th~ indKido~1 amino acid me~sure, ENC-X.to ovcrab biasoflh~ pcne,~e found~U amino icidsconidbute (gniEc~nt~ 6P ~ O.OOOl~to tbeoveraHbL~cf~genc.{kbc~ghA~p3~dr~ ou1U~ ~)
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From page 96...
... ~nd most t~ld dL~enorate T/C amino acids 1hr hi~hcs1 <~iEc~nt posL\e correlation is ~r ~ i~cre~se in C as 5ias increases. be e~eption ~ ~ ~i~ sh~s no ~cniEcanl corrclat~n in its .
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From page 97...
... 19~. A Bird argument Rinse mutation bias as ~ major cause of cordon usage bias ~ that not aH amino acids deploy the same pattern of bias.
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From page 99...
... : tl\~ I'm< At: W.A {~g (I I~}~ c: 16 ·~ ::3 ·~4 OFF i ~ ~ ~ ~ 3 ~ ~ ~ £: en, ~.
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From page 100...
... . thubottom ofFig.6 ~ouldsc~m no1to haveequalstren~lhin 1hoirch~ct~ The expected decre~seln ~nonymouspo~morphism caused by codon usage bias ~ not great cnou~b to ove~ometbeexpectedincreasc ~ suchpo~ morp~smsdue 10 lesscnin~ eOtclsofsel~ct\cs~eops.
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Key Terms

  • usage bias
  • amino acids
  • mutation bias
  • biased genes
  • amino acid

  • highly biased
  • codon bias
  • degenerate amino
  • synonymous substitutions
  • highly expressed

  • linked genes
  • expressed genes
  • fourth chromosome
  • low recombination
  • genes display

  • unequal usage
  • reduced recombination
  • synonymous substitution
  • molecular evolution
  • sequence data

  • support selection
  • prime candidates
  • maximum bias
  • observations provided
  • evolutionary periods

  • highly unlikely
  • lower rates
  • expressed copy
  • serum proteins
  • codons coding


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