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14 A Research Agenda
Pages 437-442

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From page 437...
... APPROACH The following approach was used to develop the research agenda: · Gaps in knowledge were iclentifieci in - nutrient requirements, - methodological problems related to the assessment of intake of these nutrients and to the assessment of acloquacy of intake, - relationships of nutrient intake to public health, and - adverse effects of nutrients. · Data were examined to identify any major discrepancies between intake and the Estimated Average Requirements (EARs)
From page 438...
... involves identification of the criterion for a particular status indicator or combination of indicators that is consistent with impaired status as clefineci by some clinical consequence. For many of the B vitamins, there is a dearth of information on the biochemical values that reflect abnormal function.
From page 439...
... In addition, an accurate assessment of variance requires a sufficient number of subjects. A relatively new and increasingly popular approach to determining requirements is kinetic modeling of body pools using steadystate compartmental analyses.
From page 440...
... Research to ciate has inclicateci little cause for concern about the acloquacy of pantothenic acid or biotin intake for healthy people; deficiency states can be procluceci only by actively interfering with the absorption or bacterial production of these vitamins. On the other hanci, animal studies suggest that choline intake mav affect lon~-term health.
From page 441...
... identification of an animal model for common human NTDs that is responsive to relevant levels of folate. Chronic Degenerative Disease Risk Although interest is high and numerous studies have been conclucteci, there are still serious gaps in knowledge of the relationship of B vitamin intake to risk of vascular disease and other chronic degenerative diseases.
From page 442...
... The following five areas for research were assigned the highest priority: · Studies to provide the basic ciata for constructing risk curves and benefit curves across the exposures to food folate and to folate acicleci to foocis and taken as a supplement. Such studies would provicle estimates of the risk of developing neural tube defects, vascular disease, and neurological complications in susceptible inclivicluals consuming different levels of folate.


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