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Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (1998) / Chapter Skim
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Appendix J Options for Dealing with Uncertainties in Developing Tolerable Upper Intake Levels
Pages 507-511

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From page 507...
... The most significant inference uncertainties arise in risk assessments whenever attempts are macle to answer the following questions (NRC, 1994~: · What set or sets of hazard and close-response ciata (for a given substance) should be used to characterize risk in the population of interest?
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From page 508...
... that best predicts human response, it has become traditional to select that set in which toxic responses occur at lowest dose (the most sensitive set)
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From page 509...
... For example, several scientifically supportable options for close scaling across species and for high-to-low close extrapolation will exist, but there will be no really means for identifying those that are clearly best supported. The NRC committee recommencleci that regulatory agencies in the United States identify the neecleci inference options in risk assessment and specify, through written risk assessment guidelines, the specific options that will be used for all assessments.
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From page 510...
... As will be seen in the chapters on each nutrient, specific default assumptions for assessing nutrient risks have not been recommencleci. Rather, the approach calls for case-by-case judgments, with the recommenciation that the basis for the choices macle be explicitly TABLE J-1 Approaches for Dealing with Uncertainties in a Risk Assessment Program Program Model Advantages Disadvantages Case-by-case judgments by experts Written guidelines specifying defaults for data and model uncertainties (with allowance for departures in specific cases)
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From page 511...
... 1986. Guidelines for carcinogen risk assessment.
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Key Terms

  • relevant scientific
  • true state
  • risk characterization
  • allow risk
  • inference options

  • sensitive set
  • basic knowledge
  • carcinogen risk
  • uncertainties arise
  • uncertainties inherent

  • support alternatives
  • significant inference
  • definitive empirical
  • various approaches
  • provide explicit

  • inference uncertainties
  • scientifically plausible
  • assessments whenever
  • fill knowledge
  • faithfully reflect

  • information bearing
  • model uncertainties
  • effects endpoint
  • assessment issued
  • plausible options

  • whenever attempts
  • assessors complete
  • human response
  • alternative factors
  • risk estimates


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