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Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (1998) / Chapter Skim
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Appendix L Methylenetetrahydrofolate Reductase
Pages 520-522

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From page 520...
... Most of the adverse effects associated with this polymorphism affect the homozygote and heterozygotes behave in most regards similarly to the wild type. Because of this, most studies of this polymorphism have compared the effect of homozygosity with a control group composed Of C677 subjects plus heterozyg7Otes.
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From page 521...
... If folate status is such that MTHFR levels decrease, the rate of formation of methyltetrahycirofolate should be recluceci; this would promote folate accumulation by tissues and consequently decrease plasma folate concentrations. A lower plasma folate concentration in such a case would not represent poorer folate status, merely more effective folate accumulation by tissues.
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From page 522...
... Jacques PF, Bostom AG, D'Agostino RB, Wilson PW, Belanger AJ, O'Leary DH, Wolf PA, Schaefer EJ, Rosenberg IH.
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Key Terms

  • plasma homocysteine
  • risk factor
  • poor folate
  • homocysteine concentrations
  • methylenetetrahydrofolate reductase

  • plasma folate
  • vascular disease
  • evidence suggesting
  • poorer folate
  • den heuvel

  • mthfr activity
  • control subjects
  • van der
  • common mutation
  • subjects homozygous

  • folate accumulation
  • lower plasma
  • van den
  • mthfr levels
  • erythrocyte folate

  • folate levels
  • dietary allowance
  • dietary interactions
  • regards similarly
  • den heijer

  • heterozygotes behave
  • artery disease
  • lower lymphocyte
  • folate derivatives
  • levels decrease


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