Skip to main content

Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (1998) / Chapter Skim
Currently Skimming:

Appendix M Evidence from Animal Studies on the Etiology of Neural Tube Defects
Pages 523-526

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 523...
... However, NTD phenotypes in the mouse are varied and none resembles the human in every respect. Moreover, the mechanism of action of any suspected human NTD gene will neeci to be investigated in animal models, such as mouse models containing incluceci mutations in the corresponding mouse gene or mice of appropriate genetic background that contain a mutation in the suspect gene.
Read the entire page →
From page 524...
... Methionine supplements recluce the incidence of rat embryo NTD incluceci by homocysteine in culture (Vanaerts et al., 1994~. The axial-clefects mouse mutant shows a reduction in posterior NTD penetrance after parenteral methionine in the pregnant clam at the onset of neural tube closure; however, large closes of folic acid and vitamin BE were without effect (Essien, 1992~.
Read the entire page →
From page 525...
... 1988. Common hierachies of susceptibility to the induction of neural tube defects in mouse embryos by valproic acid and its 4-propyl-4-pentenoic acid metabolite.
Read the entire page →
From page 526...
... 1981. The curly tail mouse: An experimental model for human neural tube defects.
Read the entire page →

Key Terms

  • tube defects
  • curly tail
  • folic acid
  • mouse model
  • tail mouse

  • human ntd
  • folate deficiency
  • posterior ntd
  • tube closure
  • mouse models

  • mouse neural
  • ntd incidence
  • animal models
  • human neural
  • mouse genetic

  • ntd penetrance
  • parenteral methionine
  • prenatal folic
  • ntd phenotype
  • yields posterior

  • human embryos
  • tail mice
  • especially common
  • tissue form
  • methionine supplementation

  • anencephaly equivalent
  • tube mutants
  • whereas neurulation
  • produce ntds
  • common hierachies


    • This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
    More information on Chapter Skim is available.