Hormonally Active Agents in the Environment (1999) / Chapter Skim
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Appendix A: Reproductive Effects Caused by Deithylstilbesterol
Appendix A: Reproductive Effects Caused by Deithylstilbesterol
Pages 397-406
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From page 398... ...
1992. In vivo prenatal chlordane exposure induces development of endogenous inflammatory macrophages.
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From page 399... ...
Table A-1 lists the various female and male reproductive-tract abnormalities in humans and rodents exposed prenatally to DES. Studies show that exposure to DES during the critical period of organogenesis can profoundly disturb differentiation of the reproductive organs.
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Exposure assessment for these studies was problematic because none of the study protocols restricted exposure to the critical period of testicular development, and all combined prenatal exposure to all prenatal hormones, rather than to DES alone. Because prenatal DES exposure occurred in about 1% of pregnancies, the power of these studies to isolate a DES effect is limited.
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From page 406... ...
1996 testosterone, decreased libido, increased impotence Estrogens Females Increased incidence of Taskinen et al. 1986 spontaneous abortion a Stilbene derivative (DAS: CAS 81-11-8)
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