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Addendum: Endocrine Disruptor Screening and Testing Advisory Committee
Pages 410-414

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From page 410...
... EDSTAC interpreted this charge to include the provisions of the Federal Insecticide, Fungicide, and Rodenticide Act, the Toxic Substances Control Act, and the Federal Food, Drug, and Cosmetic Act, in addition to the 1996 FQPA and SDWA provisions. Because these acts require testing on a variety of chemicals for human health and ecological effects, EDSTAC recommends that the scope of EPA's screening and testing program for endocrine disrupters should 410
From page 411...
... chemicals that have sufficient evidence of hormonal interaction and hormone-related effects and therefore require hazard assessment. Priority Setting Chemicals that are placed in the second category of having insufficient data will be prioritized for screening on the basis of exposure-related information, effects-related information, and statutory criteria, and then phased into the screen~ng program.
From page 412...
... EDSTAC recommends the following battery of assays for tier 2 testing: · two-generation mammalian reproductive toxicity study or a less comprehensive test (e.g., alternative mammalian reproductive test) · avian reproduction test · fish life-cycle test · mysid life-cycle test · amphibian development and reproduction test EDSTAC recommends that those assays be standardized and validated before final incorporation into the screening and testing program.
From page 413...
... The major conclusion of the committee is that no generally accepted, validated methods are available to screen for HAAs, and therefore a battery of different assays evaluating different end points will be necessary for reliable determinations of hormonal activity. The committee made the following general recommendations for screening HAAs: A battery of short-term assays should be developed for rapid and inexpensive screening for putative HAAs.
From page 414...
... The committee also recognizes the need to investigate further the action of HAAs in vivo and in vitro using concentrations of HAAs found in the environment.

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