Gender Differences in Susceptibility to Environmental Factors A Priority Assessment (1998) / Chapter Skim
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Appendix A: Analysis of Agency Research Portfolios
Appendix A: Analysis of Agency Research Portfolios
Pages 25-32
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From page 25... ...
, defined as studies that focus on environmental exposures at the molecular level; includes animal studies.
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From page 26... ...
Research areas represented in the portfolios provided by the agencies include work associated with some of the epidemiological studies from family exposure research; men and women are included. In others, exposure measurements were combined with epidemiological studies as, for example, in the animal models of chemically induced endometriosis.
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From page 27... ...
END 20% Environmental Protection Agency (N = 15) EE= Environmental Exposure END = Endocrinology LTCC c Long Term Chronic Care EE 24% END 1 5% EPI ~ _ _ ~ 47% MB/BS = Molecular Biology/ Basic Science EPI = Epidemiology PREV = Prevention N = 1 77 FIGURE A-1 Percentage of research portfolio by category.
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From page 28... ...
Endocrine-related research in the agency portfolios included a disproportionate amount of research on breast cancer, breast development, and hormonal breast regulation. Pregnancy outcomes, placental effects, marker enzymes, genes, in utero exposures, and the effects on female offspring, were also covered in a number of studies.
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From page 29... ...
Other future needs include a more comprehensive approach to understanding biological mechanisms and how toxicants alter biological functions. In summary, more research is needed which takes advantage of recent advances in molecular and cell biolo ,y to address how toxic compounds alter normal physiological processes, including gender-dependent targets.
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From page 30... ...
There are some pharmacokinetic, pharmacodynamic, and biological exposure models used in epidemiology that do not currently include gender. The committee suggested that the importance gender may play in these models is inadequately examined and deserves a more intense focus by investigators who choose to develop and examine these models.
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From page 31... ...
Some studies of the cardiovascular demandlcontrol model with a social support component suggest that the combination of demand, control, and support is more important than cigarette smoking in the etiology of cardiovascular disease. The committee urged researchers to look for important risk factors in cardiovascular disease, even though the technology of exposure assessment is complex and utilizes behavioral science measures.
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From page 32... ...
Nonetheless, a review of the projects identified thematic areas in which substantial research is being conducted, as well as areas in which there are gaps in research and opportunity. The committee suggested that the agencies review their research portfolios using identical definitions, expanded to include all possible adverse influences on women's health.
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