Biomedical Models and Resources Current Needs and Future Opportunities (1998) / Chapter Skim
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5. Recommendations
5. Recommendations
Pages 24-39
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From page 24... ...
Sullivan, forum co-moderator, made the following statements: · "Science cannot be highly programmed." of science." · "Opportunities must be created for young people to enter scientific fields." · "The peer-review process also plays an essential role in maintaining the vitality The committee endorses those points, and our comments on research, training and academic infrastructure below underscore these principles. The NCRR Comparative Medicine Program can play a pivotal role in enhancing the utility and availability of animal models and the quality of animal-related research and laboratory animal welfare through expanded and stabilized competitive research funding.
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From page 25... ...
Considering the trends in research based on animal models, there clearly are research areas that the NCRR Comparative Medicine Program can emphasize through program announcements. The growing importance of genetically altered laboratory mice during a period of federal austerity in spending for animal-related health care and infrastructure poses a pressing need.
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From page 26... ...
Diagnosis and infectious disease Our laboratory animal infectious-disease guard appears to be down and there is an emergence of new, as well as previously known, infectious diseases (Iacoby and Lindsey ~ 9971. Something should be done to improve infectious-disease surveillance.
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From page 27... ...
Ethologists, in particular, receive broad integrative biology training that enables them to address questions of causation, function, development, and evolution of behavior. Study sections should be organized to accommodate competent review of behavioral studies.
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From page 28... ...
NCRR cannot be the sole support for this growing need and is encouraged to continue to use its base support to leverage additional NTH institute sharing of support for such resources. In the past and today, animal-based research has relied heavily on resources and services provided by commercial producers of laboratory animals.
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From page 29... ...
DEVELOPMENT OF GENETIC MAPS FOR ADDITIONAL MODEL SPECIES There is a critical role for NCRR in furthering functional genomics studies in outbred models, particularly primates and some aquatic organisms. Such species axe outside the mission of the Human Genome Project.
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From page 30... ...
INSTRUMENTATION DEVELOPMENT AND MINIATURIZATION There was interest in and need expressed for support of developing technologies for phenotypic analysis of animals. Two major types of technology advances would enhance phenotype assessment in experimental animals: 1)
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Diagnostic methodology for laboratory animal infectious diseases has not advanced appropriately, in part because of the hiatus created by discontinuation of Diagnostic investigative Laboratory support and in part because of the naucitv of scientists involved in annlied comparative medical research. 1 ~ - - 1-1 Development of molecular diagnostic methods for laboratory animal infectious diseases is needed to reduce cost, increase efficiency, increase sensitivity and specificity, and expand diagnostic capabilities to agents of emerging significance or agents in which accurate diagnostic methods are lacking.
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From page 32... ...
Effective recruitment of outstanding candidates into residency programs and capture of the best of them for scientific training require superior academic environments and role models. Academic infrastructure also provides the opportunity for recognition and investigation of emerging and existing diseases of contemporary laboratory animal populations, such as the discovery and investigation of infectious diseases peculiar to genetically altered mice, investigation of behavioral and environmental needs of laboratory animals, and development of advanced technologies in mammalian genomics and husbandry of genetically altered animals.
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From page 33... ...
At the very least, the proposal sets the stage for NCRR to develop a vision for a comparative medicine academic infrastructure. The CMBN plan offers the cost-saving advantages of shared resources to meet the national needs of the NIH research community.
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From page 34... ...
assembly systems that are appropriately framed for biomedical research, making modelling and simulation tools available on the World Wide Web, and developing and promoting documentation, reviews, and evaluations of available software so that biomedical scientists could better select and apply existing modelling tools in their research. Development and Dissemination of Appropriate Informofion Technologies .
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From page 35... ...
Funding is also needed to build specialized animal holding facilities that can be shared by investigators using animal models, such as Level 3 biocontainment facilities for infectious disease research and facilities for unique species of animals not typically available to the biomedical research community, such as marine and aquatic animals. Such facilities fall within the realm of creating a network of facilities and expertise that support the national research effort.
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From page 36... ...
Despite its importance, residency training is not within the realm of NIH support, and laboratory animal residency training has been recently de-emphasized by NCRR. Nevertheless, NCRR can indirectly but substantially foster critically needed laboratory animal residency training through the development of academic infrastructure.
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From page 37... ...
One possible mechanism would be to solicit their input and studies through requests for proposals that focus on behavior. To improve the efficiency of animal use and facilitate humane treatment of research animals, NCRR should foster training of NIH investigators in the research use of animal models, phenotypic analysis, animal-related technology, and other issues that facilitate NIH research.
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From page 38... ...
With a properly selected committee of scientists involved in competitive scientific careers, it offers an effective means of assessing the trends and needs of the NIH research mission. NCRR has an active and interested program staff.
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From page 39... ...
organizing small workshops to assess specific fields and asking independent agencies outside NIH to convene working groups to provide reports like this one.
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