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Appendix D. Thyroid Cancer in Idaho, 1970-1996
Pages 198-213

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From page 198...
... Because four of the five counties in the United States with highest estimated exposure to iodine- 131 from atmospheric nuclear bomb tests at the Nevada Test Site are located in Idaho (Blaine, Custer, Gem, and Lemhi) , and public health services are delivered at the health district level, analyses were conducted at both the county and health district levels of geography (see Appendix for listing of counties by health district)
From page 199...
... Given the years that atmospheric nuclear bomb tests were conducted at the Nevada Test Site, and the fact that children aged 0-5 are biologically most sensitive to iodine- 131, persons born during the time period 1948-1958 are thought to have been at the risk of highest exposure. The other birth cohorts were chosen for comparison purposes.
From page 200...
... Two-tailed p-values comparing the number of observed and expected cases were calculated using the Poisson probability distribution. Observed and expected cases, and p-values, were calculated separately for males, females, and both sexes combined, by birth cohort.
From page 201...
... 4.22 = 5.29. The overall rate from Step 4 was used as the reference rate in order to facilitate comparisons across birth cohort for individual health districts and counties, and to allow comparisons among health districts and counties within birth cohort.
From page 202...
... Incidence rates varied by geographic location, ranging from 3.28 cases per 100,000 person-years in Health District 2 to 5.20 cases per 100,000 person-years in Health District 4. There were significantly more cases of invasive thyroid cancer diagnosed among residents of Health District 4 than expected based upon rates in the state of Idaho (314 observed, 254.6 expected, p<.O01)
From page 203...
... CDRI investigated thyroid cancer incidence in three birth cohorts to explore the relationship between age at the time of iodine-131 release from atmospheric nuclear bomb tests at the Nevada Test Site and thyroid cancer incidence. The number of invasive thyroid cancer cases in the state of Idaho, 1970-1996, was not statistically significantly higher than expected, based upon overall rates, for any of the three birth cohorts.
From page 204...
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From page 213...
... None of the four Idaho counties with highest estimated exposure to iodine-131 showed an elevation in thyroid cancer cases from 1970-1996 in the birth cohort born during 1948-1958, which was estimated to have received the highest exposure to iodine-131. Although the overall female-to-male thyroid case ratios differed by birth cohort, this result was confounded by age, as the cumulative agespecific ratios are similar in each birth cohort.


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