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Appendix B: Inventory of Chemical and Biological Defense Technology, with Gap and Overlap Analysis
Pages 221-259

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From page 221...
... APPENDIX B Inventory of Chemical and Biological Defense Technology, with Gap and Overlap Analysis 221
From page 222...
... Israel Ministry of Defense Export Organization (SIBAT) MSA Defense Products MSA Safety Products
From page 223...
... Geomet Technologies Giat Industries Giat Industries Giat Industries
From page 224...
... Advanced Lightweight Chemical Protection Level B Suit Level A Suit SARATOGA-Pyjama Chemical Protective Undergarment ILC Dover, Inc. ILC Dover, Inc.
From page 225...
... Improvements to existing C/B Bomb suit Engineered Air Systems (Mo) Giat Industries Giat Industries Giat Industries Giat Industries ILC Dover ILC Dover, Inc.
From page 226...
... Chemical Surety Chamber and Lab Automatic Liquid Agent Detector (ALAD) System Miniature Chemical Agent Monitor (MINICAM)
From page 227...
... Chemical Agent Monitor (CAM) Environmental Technologies Detalac Automatic Detector of Giat Industries Nerve gas agents Environmental Vapor Monitor (EVM)
From page 228...
... Spectrometer, Model 110 API 365 Microchromatography AP2C Family of Chemical Agent Detectors MINIRAE Plus Direct-Reading Tubes M9OD1-A Chemical detector Scentograph Plus II with AID/RCD Detector Scentoscreen (Gas Chromatograph) with Argon Ionization Detector SCX-20 VOC Monitor Dual Flame Photometric Detector Mine Safety Appliances Co.
From page 229...
... SOF Chemical Agent Detector w low false positives GI-MINI Miniature Chemical Warfare Detector/Monitor Rugged, portable GC-MS for CW LLNL agents Multipurpose integrated chemical agent alarm (MICAD) Shipboard Automatic Liquid Agent Detector (SALAD)
From page 230...
... Laser Remote Detector MARK 1 Detector Kit Chemical Agent Residual Vapor (RVD) Contract Labs TAGA 6000E MS/MS-triple quadrapole Mobile lab Canine detection of low level CW Wearable dosimeter indicating cumulative exposure Miniature GC-IMS Joint service lightweight standoff chemical agent detector (JSLSCAD)
From page 231...
... APPENDIX B 23 Availability Product Source or Laboratory/PI Laboratory Research Military Micro-mass spectrometer for containment gas monitoring Neuron Chip Micro unmanned chemical and biological sensor vehicle CB mass spectrometer Block 2 (CBMS II) Advanced Ion-trap mass spectrometry Capillary electrophoretic methods for monitoring spacecraft water Enzyme-FET Parallel Micro Separations-based SNL/Vitko Detection (PMSD)
From page 232...
... Air Force Global Surveillance WHO Weekly Epidemiological Record (WER) Outbreak WHO WWW Emerging Infectious Disease CDC Initiative Global Emerging Infections DoD Surveillance and Response System (DoD-GEIS)
From page 233...
... APPENDIX B Symptom-Based Diagnosis Systems 30-Sep-98 233 Availability Product Source Operational Planned Associate NBC indicator symptom matrix Global Infectious Disease and Epidemiology Network Emergindex Drugdex Poisindex Carter-Melloy Corp Defense Protective Services/ M Dougherty Gideon, USA Micromedex, Inc.
From page 234...
... Thermal cycler microvolume fluorimeter SpinCon High-volume Portable Air Sampler PathoSeq bacterial gene sequence library Modification of NMRI handheld BW tickets CB mass spectrometer (CBMS I) Biological Microchips for Field Analysis of Microorganisms Mini Mass Spectrometer for Biodetection 16S Ribosomal RNA Hierarchical Analysis Miniature Environmental Air Sampler Using Aerogel Hierarchical Analysis of Unknown Biological Samples c Affymetrix, Inc.
From page 235...
... APPENDIX B 235 Availability Product Source or Laboratory/PI Field tests Simultaneous immunoPCR and genomic PCR ALERT Lateral Flow Immunoassay Tickets Integrated Virus Detection System High speed chemical analysis of DNA by TOF-MS Interim biological agent detector (IBAD) Compact DNA-based Bacterial Identification by Flow Cytometry Antibiotic Resistance Detection BW Genetic Sequencing Self-assembling thin film biosensors Improved methods to isolate and process DNA from environmental samples Miniature PCR-based Bioagent Detector Marine Corps Unit Biological Detector DNA Dipstick Handheld Assay SMART Tickets Automated Programmable Rapid PCR assays for BW detection DuPont/Ebersole ERDEC/Emanuel and Valdes ERDEC/Wick and EnVirion, L.C.
From page 236...
... Nanoscale DNA Advanced Diagnostics Program Unmanned Aerial Vehicle-Borne Hybrid Optical Sensor Novel Biodetection by Spore specific Phosphorescen Next Generation, Integrated Biosensor Research Smart Aerogels for Application in Biowarfare Upconverting Phosphor Flow Cytometer Upconverting Phosphor Compact Novel Antibody Reagents (Immunoplastics) for Sensors Schwartz Electro-Optics Tech Escort Unit Unknown A.A.
From page 237...
... IGEN PCR Biosensor Assay NMRI/Churilla Recombinant antibodies for BW NMRI/Churilla Agents DNA Detection via Current Rectifying Oligonucleotides Northwestern U./Mirkin Force Amplified Biological Sensor NRL/Colton (FABS) A Multiplexed Immunosensor NRL/Gaber based on Lateral Force Microscopy Automated Multiagent Sensor NRL/Ligler Neuron Chip NRL/Ligler Micro unmanned chemical and NRL/R.Foch biological sensor vehicles
From page 238...
... Oak Ridge National Laboratory ONR/LLNL (Leighton) ORNL/McLuckey Pacific-Sierra Research Corp Sandia NL/Thomas SNL/Vitko, Thomas Taqman PCR-based BW assays USAMRIID Automated Nucleic Acid Extractor USAMRIID/Xohox, Inc Deployable diagnostic kit for USAMRMC biowarfare agents
From page 239...
... 2 Tradeways Lid M291 Decontamination kit for Tradeways Lid individual equipment M258 Skin decontamination kit Tradeways Lid STB super tropical bleach Unknown XM21/XM22 Modular decontamination system Wound decon systems Mediclean Spray/Suction Units Non-toxic, non-corrosive enzymebased foam decon system CBDCOM USAMRIID Karcher (Germany) Arthur D
From page 240...
... 240 CHEMICAL AND BIOLOGICAL TERRORISM Availability Product Source/Location Research Sorbent decontamination system CBDCOM Sensitive equipment decontamination Biomimetic materials Molecular decoys Enzymatic Decontamination Solid state absorber/oxidizers for CW decon CBDCOM DARPA/Molecular Geodesics, Inc.
From page 241...
... Meridian Med Commercial Tech; Quad Pharm; Wyeth Diazepam Abbott, Lederle, Commercial Parke-Davis, others Pyridostigmine bromide ICN Commercial Pharmaceuticals Atropine Meridian Med Commercial Tech: Kalli DuPhar; 3M-Reiker
From page 242...
... Acetylcholinesterase USAMRICD Preclinical USAMRICD Preclinical USAMRICD Preclinical USAMRICD Preclinical Catalytic monoclonal antibodies USAMRICD Preclinical Memantine USAMRICD Preclinical NMDA receptor blockers USAMRICD Preclinical Pro-2-PAM H series of oximes Carboxylesterase Oxygen+ventilation+ bronchodilators Aminophylline Hexamethylene tetramine (HMT) Unknown Preclinical Czech Republic Preclinical military and others USAMRICD Preclinical Other Commercial Other Commercial Other Commercial Corticosteroids Other Preclinical Cysteine (and N-acetylcysteine)
From page 243...
... M258A1 Decon kit Nitric oxide synthase inhibitors Dexamethasone /heparin/ promethazine combos Chlorox Commercial Becton Dickinson Commercial Microbiology Systems Tradeways, Ltd. Commercial (MD)
From page 244...
... 244 Biological Agent Treatments 07-Oct-98 CHEMICAL AND BIOLOGICAL TERRORISM Agent Treatment Source Availability Anthrax Bacteria Ciprofloxacin Anthrax Vaccine Doxycycline Biostructure Mapping by STEM, Cryo-EM, EELS, and SPM: Anthrax Toxin Structure-based Drug Design for Microorganism-associated Proteins Anthrax Toxin Structure and Function Control of Protective Antigen Synthesis by B anthracis.
From page 245...
... 1 Monoclonal antibodies Recombinant vaccines USAMRIID IND USAMRIID IND Thomas Jefferson Preclinical Univ. /Simpson USAMRIID Preclinical USAMRIID Preclinical USAMRIID Preclinical Chimer of botulinum toxin USAMRIID Preclinical receptor-binding protein Functional Analysis of Dengue UKansas Med Preclinical Virus Antigens NS3 and NS5 Center/ Padmanabhan Mechanisms of Immunopathology in Dengue Hemorrhagic Fever Immunologic and Epidemiologic Studies of Emerging Viruses UMass Med Ctr/ Preclinical E
From page 246...
... 246 CHEMICAL AND BIOLOGICAL TERRORISM Agent Treatment Source Availability EKE Lassa Multiple Plague Q-Fever EKE Vaccine Acute Alphavirus Encephalitis Immunologic and Epidemiologic Studies of Emerging Viruses Molecular Basis of Arenavirus Virulence Unknown IND Johns Hopkins Preclinical SPH/Griffin Scripps Res Inst/ Preclinical Buchmeier U Wisconsin/ Preclinical Salvato Naked DNA/gene gun vaccines USAMRIID Preclinical Multiagent replicon vaccines USAMRIID Preclinical Plague Vaccine Greer Commercial Streptomycin Doxycycline Plasmid PCD-Encoded Virulence Determinants in Plague Mechanism of Bacterial Metastasis in Plague Tetracyclines Q-Vax Q-Fever Vaccine Pathogenic Roles of Coxiella burnetti Surface Proteins Surface Change and Virulence in Coxiella burnetti Lilly; Pfizer Commercial Parke-Davis; Commercial Pfizer; Lederle U Kentucky/ Straley UMass Med Sch/Goguen Preclinical Preclinical Numerous drug Commercial companies Australian Foreign product IND 610 IND Texas A&M/ Preclinical Samuel Wash. State Preclinical Univ.
From page 247...
... Other Commercial Other Commercial Tradeways Ltd Commercial (MD) USAMRIID Preclinical USAMRIID Preclinical USAMRIID Preclinical
From page 248...
... Red Blood Cell Pathogen Defense-Decoy Streptomycin Tularemia Vaccine C-84 VEE Vaccine TC-83 VEE Vaccine DARPA/UVA Preclinical (R. Taylor)
From page 249...
... Antibodies Heat Shock Protein-Peptide Complexes as Anti-Viral Agents Structure-based Design of Acute Countermeasures to Viruses Prevention of Virus Assembly in Host Cells Cytotoxic T Cell Responses to Virus Infection Glycyrrhizic acid derivatives Monkeypox Virus Genome S equencmg WEE Vaccine ICN Pharmaceuticals Commercial DARPA / envision Pre clinical (E.
From page 250...
... Department of Veterans On-line Publications, Victims Open Literature Affairs database (www) National Center for PTSD Victims Disaster Mental Health Institute International Critical Incident Stress Foundation (Mitchell)
From page 251...
... and coping in military Uniformed Services Univ Psychiatry Dept. Studies, of Health Sciences advice on stress and (Ursano)
From page 252...
... 252 Computer Models 30-Sep-98 CHEMICAL AND BIOLOGICAL TERRORISM Availability Product/Model Agent Type Source Beta testing BWD Incident Repository BWDAD (Biological Warfare Defense Anchor Desk) BITLAS (Biological integration team large area simulation model)
From page 253...
... NBC Warn (Nuclear, biological, C /B and chemical warning and reporting network software) ALOHA Pgm for Response Options and C/B Technology Enhancements for Terrorism in Subways Urban Transport of CW/BW C/B Aerosols CBW Environment/Challege C /B and Mobile Force Operability Modeling and Simulation C /B Defense Special Weapons Agency Defense Special Weapons Agency OptiMetrics, Inc.
From page 254...
... In the process, we eliminated most products or R&D that did not explicitly address military chemical or biological agents or appear to be sufficiently generic in nature to encompass those agents without a major change. Exceptions were made only in categories in which there were very few or no products or R&D explicitly directed at chemical and biological weapons.
From page 255...
... With only 6 (out of 73) devices commercially available, 92% are in either the field testing stage (40%)
From page 256...
... of the chemical agent detectors are intended to detect agent in the environment, with only 4% designed to detect agent in patients. What is needed.
From page 257...
... . There are 15 entries, 12 of which are operational at this time, the Emerging Infectious Disease Initiative of the CDC, which is a long-term project just getting under way, and the Global Public Health Intelligence of Health Canada, and the DoD's Global Emerging Infections Surveillance and Response System (DoD-GEIS)
From page 258...
... Only 4 of the 22 R&D items in the inventory are focused on biological agent decontamination; 2 items pertain to both chemical and biological agents; and 13 focus on chemical agents. Thirty-six percent of the products being researched are potentially applicable to human decontamination; the remainder focus solely on decon of inanimate objects.
From page 259...
... As in biological treatments, most (53%) treatment products for chemical agents are in the preclinical stage of development; however, 35% of the chemical agent treatments are commercially available in the United States.


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