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Approach for Setting Dietary Reference Intakes, Including Tolerable Upper Intake Levels
Pages 5-5

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From page 5...
... The term "adverse effect" is defined as any significant alteration in the structure or function of the human organism (Klaassen et al., 1986) , or any impairment of a physiologically important function, in accordance with the definition set by the joint World Health Organization, Food and Agriculture Organization of the United Nations, and International Atomic Energy Agency (WHO/FAD/IAEA)

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