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Military Strategies for Sustainment of Nutrition and Immune Function in the Field (1999) / Chapter Skim
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Appendix C: Overview of Immune Assessment Tests
Pages 537-542

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From page 537...
... National Academy Press C Overview of Immune Assessment Tests BASIC TESTS OF IMMUNE STATUS The Agency for Toxic Substances and Disease Registry (ATSDR) basic panel of immune function tests consists of a group of assessments that are performed with serum and several that are performed on whole blood.
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From page 538...
... Lymphocyte subpopulations vary over time and between individuals. In addition, peripheral immune cells and compartments, although easy to sample, may not reflect immune function in the lymphoid tissues where the most significant changes in lymphocyte subpopulations are likely to occur, and samples drawn from peripheral pools may be more reflective of one part of the immune system than the other (humoral versus systemic)
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From page 539...
... Granulocyte nitroblue tetrazolium dye reduction provides an assessment of granulocyte function but should be replaced eventually by lymphocyte phenotyping. Studies of lymphocyte proliferation or function are in vitro assays of the ability of plant mitogens, lymphokines, recall antigens, or allogeneic cells to stimulate lymphocyte blastogenesis and proliferation.
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From page 540...
... Cannon (Pennsylvania State University, University Park, personal communication, 1996) , who emphasized the need to correlate cytokine production by whole blood with that of isolated blood cells.
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From page 541...
... An additional problem with cytokine assays is that the correlation between circulating levels of cytokines or their membrane receptors and functional immune status is still not well characterized (G. Sonnenfeld, University of Kentucky, Louisville, personal communication, 1997~.
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From page 542...
... The influence of exercise on IL-1 and IL-2 and on IL-2 receptors has been reviewed by Shephard and coworkers (1995~. Natural Killer Cell Activity Natural killer cytolytic activity is assessed by measuring the In viva release of radiolabeled chromium Tom target cells, usually a human myeloid tumor cell line.
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Key Terms

  • soluble receptors
  • circulating cytokines
  • immune status
  • natural killer
  • lymphocyte proliferation

  • advanced immune
  • blood samples
  • cell culture
  • culture supernatants
  • lymphocyte phenotyping

  • soluble receptor
  • assessing military
  • military performance
  • blood cells
  • exposed previously

  • lymphoid tissues
  • function assessments
  • blood cultures
  • circulating levels
  • field studies

  • recall antigen
  • performance capability
  • concurrent assessment
  • permit actual
  • target cells

  • binding proteins
  • cytokine production
  • requires identification
  • basic test
  • reflect immune


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