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An Assessment of the Health Risks of Seven Pesticides Used for Termite Control (1982) / Chapter Skim
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Chlorpyrifos
Pages 37-42

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From page 37...
... (1970) exposed volunteers to a fog containing varying concentrations of chlorpyrifos and examined ehe effects on plasma cholinesterase and red-cell cholinesterase activity.
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From page 38...
... The four men who served as unexposed controls exhibited little change in plasma cholinesterase activity during the 2-wk observation period concomitant with the exposure period of the exposed workers. From the data supplied on the number of gallons of chlo~pyrifos that each worker sprayed, it was evident that the decrease in plasma cholinesterase activity was generally related to the amount of material to which a worker was exposed.
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From page 39...
... Dosages of 0.1 mg/kg per day or less had no effect on asma and red-cell cholinesterase activity in rats, whereas 0.03 mg/kg per day was the largest dose tested that had no measurable ef feet in dogs. Higher dietary concentrations of chlorpyrifos caused significant decreases in cholinesterase activity.
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From page 40...
... When rats were given a single 5-mg dose of chlorpyrifos labeled with carbon-14 by stomach tube, 88.4 percent of the total dose was recovered in the urine within 48 h (Bakke et al., 1976~. Compounds identified in the urine Included the glucuron~de of 3,5,6-trichloro-2-pyridinol (80 percent)
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From page 41...
... To prevent significant decreases in cholinesterase activity, which court cause functional alterations, a 90-d continuous exposure limit for chlorpyrifo. of 0.10 mg/~3, derived from the no-adveree~effect level for ingestion, was recommended by the NRC Committee on Toxicology ( 1978~ .
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Key Terms

  • plasma cholinesterase
  • body weight
  • preexposure values
  • cream samples
  • significant decreases

  • minute volume
  • feeding studies
  • exposure period
  • cholinesterese activity
  • ant treatment

  • doing light
  • ice chlorpyrifos
  • plasma ant
  • continuous exposure
  • spraying period

  • potent chol
  • exist ing
  • treated animals
  • cited data
  • normal effects

  • parent compound
  • dermal applications
  • cholinergic symptoms
  • inhaled chl
  • samples hat

  • toxic effects
  • maternal toxicity
  • ignif icant
  • inhalation data
  • acute exposure


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