An Assessment of the Health Risks of Seven Pesticides Used for Termite Control (1982) / Chapter Skim
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Conclusions and Recommendations
Conclusions and Recommendations
Pages 43-50
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From page 43... ...
Because chlordane is the most widely used termiticite in military housing, the following comparisons of risk are made with reference to it. COMPARIS ON OF CARC INOGENIC RISK There are insufficient data to determine whether carcinogenicity is the critical biologic end point in humans exposed to these pesticides, but available animal data allow some useful comparisons of risk.
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From page 44... ...
could yield quite different estimates, and they rely to some extent on subjective judgment about the nature of the dose-response curves beyond the experimental data and on assumptions about the unknown effects of potential species differences in metabolism, physiology, and carcinogenic processes. Because of these uncertainties, some are of the opinion that the magnitude of cancer risk cannot be ret iably es timated (NRC, 197 7a)
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From page 45... ...
lone carcinogenic rise varies to some extent; NCI mouse bioassays have suggested that Aldrich, dieldrin, and heptachlor have a greater carcinogenic risk than chlordane. However, the dif f erenc e is no t suf f ic lent to make one termit ic id e more des irabl e than another solely on the basis of health risk.
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From page 46... ...
Because chlorpyrifos is not as persistent as chlordane and needs to be applied more often to be effective, there is a potential for higher airborne concentrations, which could increase the 1 ikel ihood of acute ef fecte. RECO - ENDAT IONS GUIDELINES FOR A _ ISIS 11~1~111" The airborne exposure li~te suggested here are intended to provide guidance in estimating the health risks of the pesticides in military housing.
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From page 47... ...
, these reports do not provide information on the health risks in humans and animals associated with various degrees of exposure to airborne chlordane. Because of the shortcomings of current data and in view of the request thee more definitive data be developed, the airborne concentration for chlortane of 5 ~g/~3 should be regarded as an interim guideline for exposures not exceeding 3 ye.
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From page 48... ...
If is is assumed that all this inhaled material would be absorbed into the blood, the guidelines for airborne exposure compare favorably with the blood concentrations associated with no observed adverse effects. For example, with 100 percent absorption and assuming a blood volume of 5 L and a daily volume of inspired air of 20 m3, exposure of dieldrin at 1 ug/m3 would result in a blood concentrat ion of 4 ~ g/ L
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From page 49... ...
Published quantitative analytic data were available to the Committee only on chlordane; some preliminary data were available on aldrin and dieldrin. The Committee suggests a program to determine the airborne concentrations of the termiticite.
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From page 50... ...
The Committee now reco~ende that, at a minimum, a biologic monitoring program be undertaken as a first step in a comprehensive analysis of the human health effects of chlordane. Concentrations of chlordane and its metabolites in fat, blood, and urine of persons known to have lived in military housing where culordane was applied should be measured.
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