An Assessment of the Health Risks of Seven Pesticides Used for Termite Control (1982) / Chapter Skim
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Chlordane
Chlordane
Pages 9-18
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From page 9... ...
Technical chlordane is usually sold as an emulsifiable concentrate for use in dilute water suspension as a spray, but is also supplied in powder form diluted with talc or other inert mineral dust (Aldrich and Holmes, 1969)
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From page 10... ...
Acute poisoning associated with spraying, manufacture, or accidental ingestion of cyclodienes produces central nervous system symptoms, including headache, blurred vision, dizziness, alight involuntary muscular movements, tremor, sweating, insomnia, nausea, and general malaise. More severe illness is characterized by involuntary contractions of muscles or groups of muscles ant by epileptifonm convulaione, with lose of consciousnese, urinary ant fecal incontinence, disorientation, personal ity changes, psychic disturbances, and lose of memory.
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From page 11... ...
Occupational Exposure Princi and Spurbeck (1951 ) evaluated 34 persons engaged in the manufacture of insecticides, including chlordane, and exposed through skin contact and inhalation for 11-36 mot Physical examinations, chest x rays, urinary dilution and concentration tests, complete blood coupes, routine urinalysis, hemoglobin measurement, sedimentation rate, and urinary porphyrin determinations failed to suggest any abnormalities in the men.
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From page 12... ...
Data obtained from death records, social security records, and employment History of 1,403 workers employed for longer than 3 ma in the production of the two compounds indicated no overall excess of teethe from cancer. While there were fewer deaths than expected overall for diseases of the circulatory system, there was a statistically significant excess of deaths from cerebrovascular disease (17 observed vet 9.3 expected)
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From page 13... ...
concluded that there was no evidence to indicate that current or past workers at Velaicol are at an increased risk for heal th relates problems. However, the suggestion of a trend in cancer deaths with duration of employment indicates thee more complete data are needed before firm conclusions can be reached with regard to the carcinogenicity of chlordane in humane.
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From page 14... ...
Frings and O'Tousa (1Sl50) exposed 60 female mice to airborne chlordane; 16 for up to 16 wk at an airborne concentration estimated to be 25-50 percent of saturation and the remainder for up to 4 t to air saturated with chlordane.
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From page 15... ...
The principal signs of toxicity of chlordane were necrologic ; the chief pathologic changer were enlarged ant fatty 1 ivers and subeerosal hemorrhages. Chronic Exposure and Care inogenic ity Lehman (1952)
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From page 16... ...
Feeding the pure cis ant bane isolate separately indicates that the cis isomer is more effectively e} if - ted from the rats than the tasks Isomer. Al though the difference is not large, the data indicate that, with locaters exposure, trane-chlordane would contribute more to the body burden of the exposed animals than would ci~chlordane.
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From page 17... ...
An acceptable daily tose for man has been estimated to be O.OO1 mung body weight (WHO/FAD, 1968~. Although a limit of 3 ug/L was original 1 y sugges ted f or chl ordane under the proposed Interim Primary Drinking Water Standards (EPA, 1975a)
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From page 18... ...
~6. Canada nas established a tentative maximal permissible limit for chlordane of 3 ug/L, applicable to raw~water supplies (EPA, 1979a)
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