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Emergency and Continuous Exposure Limits for Selected Airborne Contaminants Volume 1 (1984) / Chapter Skim
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Acrolein
Pages 27-34

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From page 27...
... (1960) exposed human volunteers to acrolein for 5 mini 0.6 ppm caused slight eye irritation, 1.3-1.6 ppm caused mild irritation, and 2-2.3 ppm produced severe irritation.
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From page 28...
... (1963) observed a significant decrease in respiratory frequency and a ~ ignif leant increase in topical respiratory flow resistance and tidal volume in guinea pigs after exposure to acrolein at 0.4-1 e O ppm for 2 h.
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From page 29...
... At the highest concentration, weight gain was significantly reduced by the sixth week in the healthy animals and by the fifth week in the animals with silicosis; there was a change in the chronaxy of antagonistic muscles in both healthy and silicotic animals and a sharp change (not specified) in blood cholinesterase activity.
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From page 30...
... The dogs had confluent bronchial pneumon i a . INHALATION EXPOSURE LIMITS In 1976, the Committee on Threshold Limit Values of the ACGIH established a TLV of 0.1 ppm; this limit was considered sufficiently low to minimize, but not entirely prevent, irritation in all exposed persons.
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From page 31...
... The animal data available when the Committee on Toxicology made its tentative recommendations were derived from short-term, high-concentration exposures, and it appears that they were not considered useful for purposes of recommending EELs or CELs. On the basis of the human data given earlier, which represent the most extensive human experience available, the Committee's previous tentative recommendation of a 0.
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From page 32...
... other subjects in same study, average threshold concentration of acrolein for irritation was 0.09-0.30 ppm.
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From page 33...
... 1976. Threshold Limit Values for Chemical Substances and Physical Agents in the Workroom Environment with Intended Changes for 1976.
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From page 34...
... 1930. Acrolein as a warning agent for detecting leakage of methyl chloride from refrigerators.
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Key Terms

  • guinea pigs
  • eye irritation
  • ppm produced
  • community air
  • continuous exposures

  • tidal volume
  • threshold limit
  • quality committee
  • limit values
  • governmental industrial

  • american conference
  • sixth week
  • industrial hygienists
  • silicotic animals
  • blinking rate

  • normal throughout
  • inflammatory changes
  • respiratory resistance
  • human volunteers
  • appeared normal

  • squamous metaplasia
  • ppm caused
  • tentative recommendations
  • exposure data
  • eye blinking

  • minute volume
  • exposure limits
  • animal data
  • antagonistic muscles
  • fifth week


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