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Arsine
Pages 35-40

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From page 35...
... Guinea pigs exposed to arsine at 0.5-2.0 ppm 1-3 hid for up to 144 h showed evidence of decreases in red and white blood cell counts and hemoglobin concentration (Nau et al., 1944~; there was also some evidence of peripheral nerve damage. There have been numerous cases of accidental arsine poisoning (mostly acute)
From page 36...
... COMMITTEE RECOMMENDATIONS EXPOSURE LIMITS Previous EEL and CEL recommendations made by the Committee (1961 and 1 966 ~ for ars ine exposure are as fat lows: Concentrat ions, ~pm Duration 1961 1966 _ 1 h 1.0 1.0 8 h 0.05 ~~ 24 h 0.01 0.1 90 d -- 0.01 There is little additional information available for revising the 1966 recommendations and additional animal toxicity studies are necessary for the determination of an appropriate CEL. The Committee, thus, recommends that the 1-h and 24-h EELs be 1.0 and 0.1 ppm, respectively; these concentrations agree with the estimates provided by Gates et al.
From page 37...
... a ConcentrationDuration of Mortality,a Estimated Duration . mg/L ppm Exposure ~ for 50Z Mortality 2.5 783 0.50 min 93 0.40 min 0.33 min 20 1.0 313 1.25 min 57 1.18 min 0.83 13 0.50 157 10 min 100 2.4 min 5 min 93 2.5 min 57 1.7 min 0 0.25 78.3 15 min 70 12 min 9 min 33 0.10 31.3 70 min 100 50 min 50 min 50 0.025 7.8 30 h 100 24 h 27 h 50 24 h SO 21 h 50 18 h 0 15 h 0 al~hirty mice in each experiment with arsine at 0.1 to 2.5 mg/L; six mice used in each experiment with arsine at 0.025 mg/L.
From page 38...
... 2 mg/m3 " Sweden 1975 0.05 mg/m3 " Czechoslovakia 1969 0. 2 mg/m3 " USSR 1972 0.3 mg/m3 (ceiling value)
From page 39...
... Associazione Italiana degli Igienisti Industriali. Valori Limite Ponderati degli Inquinanti Chimici e Particolali degli Amiqienti di Lavoro Per I1.
From page 40...
... 2 mg/m3 " Sweden 1975 0.05 mg/m3 " Czechoslovakia 1969 0. 2 mg/m3 " USSR 1972 0.3 mg/m3 (ceiling value)


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