Emergency and Continuous Exposure Limits for Selected Airborne Contaminants Volume 1 (1984) / Chapter Skim
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Acetone
Acetone
Pages 5-26
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From page 5... ...
Solubility: Miscible with water in all proportions ; miscible with alcohol, dimethylformamide, chloroform, ether, and most oils Stability: Chemically stable liquid General characteristics: A colorless liquid with a pungent odor and taste; volatile and extremely flammable; forms explosive mixtures with air or oxygen. Other chemical properties: Forms crystalline compounds with alkali bisulfites ; reducing agents convert it to isopropyl alcohol (Hays, 1958 )
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In a study of the care inogenic potential of prostaglandins, control male albino Swiss mice treated topically with only acetone - 6
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Acetone clearance from the blood of a 68-kg man given acetone orally at 80 mg/kg was determined from alveolar air concentrations and compared with the rat clearance rate. Blood acetone started at 72 mg/L, and disappeared in 27 h; in rats, disappearance took only 10.5 h.
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INHALATION EXPOSURE LIMITS Table 5 lists the recommended occupational exposure limits for acetone in various countries. The American Conference of Governmental Industrial Hygienists (1980)
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reported that Italian workers exposed to 700-1,000 ppm for 3 hid over 7-15 yr showed inflammation of the respiratory tract, stomach, and duodenum and occasional attacks of giddiness and asthenia. At 1, 000 ppm, they excreted acetone at 160 mg/L in urine.
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From page 10... ...
, it is suggested that information on the following sub Sects be obtained: Cataract format ion: The marked abil ity of acetone to produce cataracts in the guinea pig suggests that chronically exposed workers be examined to determine whether man is similarly affected. Chronic health effects in workers: Available data are insufficient for determining chronic health effects in workers.
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a: c, :~ ·O ~ c at - ~ c .
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e or -~ oc ~o -· g 0 c ~ ~ -1 I
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From page 21... ...
Ind. filth., 1971 a TWA = time-weighted average concentration; C = ceiling concentration.
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1978. Effect of repeated exposure of mice and rats to concentrated toluene and acetone vapors.
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1963. The injection of chemicals into the yolk sac of fertile eggs prior to incubation as ~ toxicity test.
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Valori Limite Ponderati degli Inquinanti Chimici e Particolati degli Amgienti di Lavoro Per I1.
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(Acetone, methyl ethyl ketone, diacetone alcohol, methyl isobutyl ketone and methyl n-butyl ketone)
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From page 26... ...
Valori Limite Ponderati degli Inquinanti Chimici e Particolati degli Amgienti di Lavoro Per I1.
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