Emergency and Continuous Exposure Limits for Selected Airborne Contaminants Volume 1 (1984) / Chapter Skim
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Fluorine
Fluorine
Pages 77-88
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From page 77... ...
Fluorine is also used as an oxidant in rocket-fuel mixtures (ACGIH, 1980~. EFFECTS ON HUMANS Uncontrolled Exposure SUMMARY OF TOXICITY INFORMATION Women and children living in a village in the vicinity of an aluminum factory in northern Italy suffered blemishes that were thought to have resulted from stack effluents, among which might have been fluorine or fluorides (Cavagna et al., 1969~.
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From page 78... ...
observed nine male volunteers exposed to F2 under controlled conditions. Most of the subjects found that 15-25 ppm caused some nasal and eye irritation after two or three breaths.
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From page 79... ...
In rats, mice, guinea pigs, and rabbits, ef fects observed after exposures at approximately 507 and 257 of the LCso values were not observed at approximately 12.5% of the LCso values (see Tables 20-23 ~ . The lack of data an the LCso value for dogs prevents determination of whether the same pattern holds for this spec ies.
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From page 80... ...
The previously cited data support such a conclusion, and no recent data are available to suggest changes in the 10-min EEL. EELs for 30 and 60 min cannot be derived by cons iteration of the human exposure data, because exposures did not exceed 15 min.
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From page 81... ...
5 Very irritating to eyes ant nose; no aftereffect alLeplinger ant Suisea, 1968.
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From page 82... ...
300 174 79 38 Rabbit (New Zealand ~ 410 134 51 26 aKeplinger ant Suissa, 1968. Tonic Signs Marked irritat ion of eyes and respiratory tract; dyspnea Irritat ion; dyspnea Eye irritation; slight dyspnes None None Marked irsitat ion of eyes and respiseto" tract; dyspnes Trritat ion; dyspnea S1 i8ht dyspnea; isritat ion None None Irritation; dyspnea Slight dyspnea None None Gross Lung Pathology Severe diffuse congestion Moderate diffuse congest ion Mild diffuse congestion tio change No change Severe diffuse congestion Moderate diffuse congestion Very mild diffuse congestion No change No change Moderate diffuse congestion No change No change No change bThe text of the report is unclear in the otter of the sex and number of ani~le used.
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From page 83... ...
87 None Very mild diffuse congestion 65 None tto change Guinea pig198 Irritation; dyspnea Mild diffuse congestion (New England) 100 None Very mild diffuse congestion 70 None No change Dog 93 Eye irritation Slight congestion (unspecified)
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From page 84... ...
70 35 18 113 ~7 32 16 135 71 32 19 aReplinger and Suissa, 1968. Toxic Signs Irwin at ion o f eye ~ and nose; ~ light dyspnea None None None Irritat ion and dyspnea None None None Trritat ion None None None Gross Lung Pathology Moderate d i f fuse conges t ion itery mild diffuse congestion No change No change Mild diffuse congestion Very mild diffuse congestion No change No change Hi Id d i f fuse conges ~ ion Very mild diffuse congestion No change No change bThe text of the report is unclear in the matter of the sex and number of animals used LC,~ determinations were made with to animals per group.
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From page 85... ...
75 ~ apnea Mild diffuse congestion 50 None Very mild diffuse congestion 30 None No change Guinea pig135 Irritation; dyspnea Mild diffuse congestion (New England) 7 5 None No change Dog93 Irriteeion; cough; alight Smull areas of hemorrhage (Unspecified)
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From page 86... ...
N ~ normal or no change; P 3 some pathology; 1,2,3,4 ~ degree of gross lung pathologic change (1 mildest and 4 most se~rere)
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From page 87... ...
U.S. Air Force Flight Training Command, TR-59-21.
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From page 88... ...
Windholz, M., Budavari, S., Stroumhsos, L.Y., and Fertig, M.N.
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