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Emergency and Continuous Exposure Limits for Selected Airborne Contaminants Volume 2 (1984) / Chapter Skim
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Fluorocarbon 11
Pages 26-33

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From page 26...
... FC-ll may be a contaminant of submarine atmospheres. EFFECTS ON HUMANS l SUMMARY OF TOXICITY INFORMATION Inhalation of fluorocarbons during the years 1960-1970 was a prominent cause of abusive death among teen-agerse Severe cardiac arrhythmia -- resulting from light plane anesthesia and intensified by hypercapaia, stress, or activity -- was suggested as an explanation for 110 cases of sudden sniffing death (Bass, 1970~.
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From page 27...
... Recovery of administered radioactivity in exhaled air was essentially complete (99% and 79%~. Errors in collection of rapidly eliminated gases account for the differences from 100%.
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From page 28...
... (1973) studied nonanesthetized dogs and reported that the average blood concentrations of FC-ll associated with cardiac sensitization were 28.6 ~g/L in arterial and 19.7 ~g/L in venous blood.
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From page 29...
... No adverse effects have been observed in dogs, monkeys, guinea pigs, or rats continuously exposed to FC-ll at 1,000 ppm for 90 d or in a similar group repeatedly exposed at 10.250 DDm.
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From page 30...
... 1966 1984 60~min EEL 30,0001,500 ppm 24-hr EEL 20,000500 ppm 90-d CEL 1,000100 ppm -30
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From page 31...
... . Threshold Limit Values for Chemical Substances and Physical Agents in the Work Environment with Intended Changes for 1983-1984.
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From page 32...
... Newark, Delaware du Pont de Nemours & Co., Haskell Laboratory for Toxicology and Industrial Medicine.
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From page 33...
... to investigate the fate of inhaled fluorocarbons in man and in the rat Thorax 29:99-103.
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Key Terms

  • guinea pigs
  • dogs exposed
  • american conference
  • industrial hygienists
  • cardiac sensitization

  • governmental industrial
  • exhaled air
  • exercising dogs
  • cardiac arrhythmia
  • threshold limit

  • sniffing death
  • sudden sniffing
  • inhalation exposure
  • laboratory animals
  • limit values

  • cancer institute
  • inhaled fluorocarbon
  • chemical substances
  • exposed dogs
  • chronic studies

  • information inhalation
  • bronchopulmonary disease
  • aerosol product
  • intended changes
  • cardiopulmonary toxicity

  • healthy subjects
  • arrhythmias associated
  • cardiac arrest
  • permissible exposure
  • light plane


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