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Fluorocarbon 21
Pages 41-45

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From page 41...
... Contact of propylene glycol solutions of FC-21 with the skin of guinea pigs produced mild irritation at FC-21 concentrations of 25-40% (Goodman, 1976; Hood, 1964a)
From page 42...
... No compound-related effects were seen in dogs exposed at 1,000 ppm. Another incomplete 90-d study reported gross pathologic changes in the livers of rats exposed at 500 ppm, probable changes at 200 ppm, but no gross effects at 50 ppm (Allied Chemical, unpublished report to TLV Committee, 19783.
From page 43...
... On the basis of the subchronic data in animals, which suggest that the toxicity of FC-21 is greater than that of other fluorocarbons and similar to that of chloroform, the Committee has applied an uncertainty factor of 1,000 to the minimal-effect concentration in dogs and recommends a 90-d CEL of ~ ppm. For a single 24-h exposure, a somewhat higher concentration would be expected not to have adverse effects, and a 24-h EEL of 3 ppm is recommended.
From page 44...
... du Pont de Nemours and Co., Haskell Laboratory for Toxicology and Industrial Medicine.
From page 45...
... du Pont de Nemoure and Co., Haskell Laboratory for Toxicology and Industrial Medicine.


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