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Vaccines Against Malaria (1996) / Chapter Skim
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1 Summary
Pages 1-5

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From page 1...
... In spite of growing scientific optimism, however, the pace of vaccine development appears to be slowing because of diminishing public funds, fragmented public sector efforts, and limited interest within the vaccine industry. PROJECT CHARGE In view of the deteriorating global malaria situation and the urgent need for new and effective control measures, the IOM was asked by a consortium of 1
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From page 2...
... federal government can help expedite more rapid and efficient development of promising malaria vaccine candidates. To accomplish this task, the IOM convened the Committee on Malaria Vaccines, a group of six members reflecting a broad range of expertise in microbiology, parasitology, vaccine research and development, molecular biology, epidemiology, and the conduct of vaccine field trials and related issues.
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From page 3...
... Each sector has unique capabilities to contribute, but the public sector must take the lead, given the costs of vaccine research and development and present beliefs that elected returns on investment will cover only a portion of the research and development outlay. The pharmaceutical and biotechnology industries must play a major role in resolving technical issues relating to appropriate expression and purification of antigens, vaccine formulation, and manufacturing technology, but new industrial development efforts will come only in conjunction with a successful, coordinated public sector effort that first proves the feasibility and value of a given technical approach.
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From page 4...
... development efforts on a limited number of the most promising malaria vaccine candidates. The board should monitor progress in malaria vaccine development in both the public and private sectors; identify development needs, opportunities, and priorities and advise interested parties and Finding agencies of these findings; provide financial and other support for high-priority development efforts; and encourage collaboration among academia and private and public sector entities.
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From page 5...
... Some examples of precedents that may be examined for relevance to elements of the board include the 1941 Commission on Influenza of the Armed Forces Epidemiology Board, the National Task Force on AIDS Drug Development, and the National Foundation for Infantile Paralysis. · The board should commission independent market analyses to assess potential global markets-both private and public-for each of the types of malaria vaccine.
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Key Terms

  • vaccine development
  • malaria vaccines
  • public sector
  • vaccine research
  • vaccine candidates

  • promising malaria
  • effective malaria
  • field trials
  • successful development
  • impressive strides

  • vaccine industry
  • evaluate current
  • appropriate expression
  • novel adjuvant
  • scientific optimism

  • organizational elements
  • public funds
  • related research
  • board include
  • protective vaccine

  • developing effective
  • mosquitoes responsible
  • national task
  • malaria research
  • developing malaria

  • community work
  • industrial sector
  • infantile paralysis
  • vaccine formulation
  • common goal


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