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Vaccines Against Malaria (1996) / Chapter Skim
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2 Malaria: The Deteriorating Situation
Pages 6-10

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From page 6...
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From page 7...
... With the return of infected veterans after World War II, the Korean War, and the Vietnam War, and the amva1 of infected Southeast Asian refugees, reports have confirmed transmission of malaria by indigenous anopheline mosquitoes to U.S. residents who had never left the country (Luty et al., 1967; Maldonado et al., 1990)
From page 8...
... CURRENT STRATEGIES FOR MALARIA CONTROL Drug-Based Control Strategies Although antimalarial drugs are necessary to prevent death and complications in severely ill patients, they are not sufficient for malaria control. Most developing countries recommend antimalarial treatment only for symptomatic infections, because treating all infections would produce relatively small health benefits in proportion to the cost, would exacerbate selection for drug-resistant parasites, and could impair the development and boosting of natural immune responses.
From page 9...
... GOALS AND TARGET POPULATIONS FOR MAI^RIAVACCINES The complex life cycle of the malaria parasite has complicated vaccine development efforts (see Hoffman 1996 for a description of the Plasmodium life cycle)
From page 10...
... Vaccines These vaccines are directed toward blocking infection of mosquitoes. As a result, such vaccines would not have any effect on the clinical manifestations of malaria in an individual, but could have major impact through reducing malaria transmission, and thus malaria mortality and morbidity at the population (community)


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