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Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants Volume 1 (1994) / Chapter Skim
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B9: Octamenthyltrisiloxane
Pages 169-176

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From page 169...
... Johnson Space Center Toxicology Group Biomedical Operations and Research Branch Houston, Texas PHYSICAL AND CHE1\IICAL PROPERTIES Organosiloxane polymers (silicones) have high thermal and chemical slability and unusual release from sticking and surface properties (Rochow, 19511.
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From page 170...
... such low retention based on octanol:water partitioning coefficients. Apparently, rapid evaporation of the lower molecular weight components (including MDM)
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From page 171...
... for 2 y. No adverse effects were observed based on growth, mortality, gross appearance and behavior, hematology, blood urea nitrogen, organ weights, hepatic lipid, and histopathology of tissues.
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From page 172...
... This effect is not relevant to the inhalation route of administration because the effect is induced by local "lubrication" of the gastrointestinal tract. More rats died after oral adm~niskabon of DMPS than HMDS; however, that occurred only at the extreme dosage of 50 mL/kg and is not pertinent to the inhalation route.
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From page 173...
... Histological changes were not found in these organs or any of He others examined in tills limited study. It was also reported Hat 20 7-h exposures of guinea pigs to 4400 ppm caused only a 10% decrease in body weight without effect on organ weights or histopa~ology.
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From page 174...
... Rounding off He values calculated above, the SMACs are set as shown below: TABLE 9-2 Spacecraft Maximum Allowable Concentrations Duration ppm mg/m3 Effect 1 h 400 4000 Lethality 24h 200 2000 Lethality, kidney, liver 7d 100 1000 Kidney, liver 30d 20 200 Kidney, liver 180 d 4 40 Kidney, liver REFERENCES Achauer, B.M.
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From page 175...
... 1975. Volatile organic components in the Skylab 4 spacecraft atmosphere.
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Key Terms

  • silicone oils
  • guinea pigs
  • soft tissue
  • molecular weight
  • inhalation route

  • ppm caused
  • tissue augmentation
  • body weight
  • lower molecular
  • allowable concentrations

  • toxicity studies
  • spacecraft maximum
  • maximum allowable
  • commercial silicones
  • ill effects

  • repeated exposures
  • organ weights
  • bracket mdm
  • action similar
  • laxative action

  • organosiloxane polymers
  • tissue reaction
  • oral administration
  • intramuscularly produced
  • min due

  • bronchial antifoam
  • respiratory failure
  • fluids designed
  • foam suppressant
  • dermal implants


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