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Appendix A: Selection of Vaccine Candidates for Accelerated Development
Pages 143-148

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From page 143...
... The knowledge required to determine the feasibility of accelerated development covers a wide spectrum, from characteristics of the pathogen to the composition of the target population. The latter is important not only for cost-effective vaccine delivery, but also to determine whether there is sufficient motivation to achieve reasonable utilization.
From page 144...
... ACCELERATED VACCINE DEVELOPMENT AND BASIC RESEARCH PRIORITIES The criteria for selecting candidates for accelerated vaccine development do not address the general question of which vaccines are most needed in the developing world or its particular regions. For some diseases that impose major burdens, the knowledge base is insufficient to allow consideration of accelerated vaccine development by NIAID.
From page 145...
... were either included in the full subjected to further review by a committee subgroup which consulted with experts on relevant vaccine development efforts. Appendixes D-1 through D-l9 describe the prospects for immunizing against the candidate pathogens, and the supplement to this volume describes prospects and knowledge gaps for a range of diseases prevalent in the developing world and for which accelerated development efforts are not feasible or appropriate at this time.
From page 146...
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From page 147...
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From page 148...
... Shigella Rotavirus Campylobacter Filariasis Giardiasis Gonorrhea Hantaan virus Hemophilus influenzas type B Invasive alsease Hepatitis A Hepatitis B Influenza virus Japanese encephalitis Leishmaniasis Leprosy Malaria Measles Meningococcal meningitis Onchocerciasis Skin disease River blindness Pertussis Rabies Respiratory infections Parainfluenza Respiratory syncytial virus Adenovirus Streptococcus pneumoniae Hemophilus influenzas Schistosomiasis Streptococcus group A Streptococcus group B Trichuriasis Trypanosomiasis African South American Tuberculosis Typhoid Yellow fever TABLE A.3 Pathogens Not Included as Candidates but Discussed in the Committee's First Report (Appendix B) _ Acquired immune deficiency syndrome agent Adenovirus (respiratory disease)


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