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EXECUTIVE SUMMARY
Pages 1-6

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From page 1...
... Until recently, Halon gases were the major components of fire extinguishants and were used extensively in fighting fires. Because CFCs anct Halon gases have been produced and used in large quantities, any chemical that replaces them on a large scale must have relatively low risks associated with its production, use, and disposal, as well as minimal toxicity and impact on the environ meet.
From page 2...
... for HFC 134a and identify appropriate research to fill data gaps. Similarly, the Air Force requested that the NRC evalu ate the adequacy of the l min EEGL proposed by Air Force tow cologists for exposure to HCFC 123.
From page 3...
... There fore, uncertainty factors are necessary when performing risk assess
From page 4...
... Fetotox~c effects, such as a slight retardation of skeletal ossification, were observed in rats and rabbits at lower concentrations than those producing cardiac sensitization in dogs, but the NOAELs (20,000 ppm for rabbits exposed for 78 hr and 10,000 ppm for rats exposed for 240 hr) iclentified in the rat and rabbit tests cannot be used to establish a ~ hr EEGL because the animals were exposed to HFC 134a for much longer periods.
From page 5...
... 50,000 ppm as the NOAEL Using the NOAEL of 50,000 ppm, the subcommittee cleterminect the 90 clay CEGL to be 900 ppm (50,000 ppm divided by an uncertainty factor of 10 to account for interspecies variability, a factor of 4 for a 24 hr/ciay exposure vs. a 6 hr/day exposure, and a factor of 5/7 for a 7 days/wk exposure vs.
From page 6...
... Therefore, the subcommittee recommends that the l min EEGL of 19,000 ppm proposed by the Air Force be towered to 1,900 ppm.


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