Health Effects of Permethrin-Impregnated Army Battle-Dress Uniforms (1994) / Chapter Skim
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12 SUMMARY OF RECOMMENDATIONS
12 SUMMARY OF RECOMMENDATIONS
Pages 107-112
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From page 107... ...
The toxic end points evaluated were acute and subchronic toxicity, dermal and ocular toxicity, neurotoxicity, liver and other organ toxicity, immunotoxicity, reproductive and developmental toxicity, genotoxicity, and carcinogenicity. In addition, the report includes discussion on pharmacokinetics, exposure assessment, and carcinogenic risk assessment of permethrin.
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From page 108... ...
The average daily lifetime internal dose for garment workers was calculated to be 3.0 x 10~5 mg/kg per day, less than half the daily dose calculated for military personnel. That dose is only for dermal exposure from direct contact with permethrin-treated cloth and does not include possible exposure to permethrin by inhalation or ingestion of permethrin-impregnated airborne particles.
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From page 109... ...
The interactive effects can probably be minimized if the areas of the body covered by permethrin-impregnated BDUs are not also covered by DEET. DERMAL TOXICITY Review of the available information on dermal toxicity of permethrin indicates that permethrin might be a skin sensitizer at high doses in guinea pigs, although the Draize repeat insult patch test in IS4 human subjects did not cause any dermal sensitization.
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From page 110... ...
· The subcommittee recommends that immunotoxicological studies be performed in laboratory animals to ascertain the immunotoxic properties, if any, of permethrin in the mammalian species. These studies should follow the recommendations for conducting additional research as presented in the 1992 National Research Council report entitled Biologic Markers in Immunotoxicology.
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From page 111... ...
The subcommittee believes that the weight of evidence suggests that permethrin does not produce gene mutations but is a potential cIastogen in certain in vitro systems. · Three in vitro studies from one laboratory showed small statistically significant increases in the clastogenic effects of permethrin.
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