Health Effects of Permethrin-Impregnated Army Battle-Dress Uniforms (1994) / Chapter Skim
Currently Skimming:
7 LIVER AND OTHER ORGAN TOXICITY OF PERMETHRIN
7 LIVER AND OTHER ORGAN TOXICITY OF PERMETHRIN
Pages 73-76
The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.
From page 73... ...
Female rats exhibited an increase in liver weight and in liver-to-body-weight ratio when fed a diet containing permethrin at 1,000 mg/kg of diet, whereas that effect was observed in male rats at 2,500 mg/kg of diet (Clapp et al., 1977b)
|
From page 74... ...
; the NOEL for hepatic enzyme induction was estimated to be 25 mg/kg and the LOEL to be 50 mg/kg (CEPA, 1992~. OTHER ORGAN TOXICITY Human Data No organs have been identified as showing lesions related to permethrin exposure.
|
From page 75... ...
Ultrastructurally, there is an increase in endoplasmic reticulum, which is reflected in an increase in microsomal enzymes and serum enzymes specific to the liver. The NOAEL for hepatocellular hypertrophy in rats has been estimated to be 10 mg/kg per day based on a LOEL of 50 mg/kg after 2 years of dietary exposure, and the NOEL for hepatic enzyme induction has been estimated to be 25 mg/kg based on a LOEL of 50 mg/kg.
|
From page 76... ...
However, in the absence of data from dermal exposure studies, extrapolation from other routes is done by default. In general the dermal toxicity of chemical contaminants is less than the oral toxicity, because less chemical is absorbed dermally than orally.
|
Key Terms
This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
More
information on Chapter Skim is available.