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Health Effects of Permethrin-Impregnated Army Battle-Dress Uniforms (1994) / Chapter Skim
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9 REPRODUCTIVE AND DEVELOPMENTAL TOXICITY OF PERMETHRIN
Pages 79-86

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From page 79...
... Environmental Health Criteria (TPCS, 1990) and the California Environmental Protection Agency's Risk Characterization Document (CEPA, 1992~.
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From page 80...
... Maternal toxicity was seen at 150 mg/kg, and reduced fetal body weight and delayed ossification were seen at 150 mg/kg. The maternal and developmental NOAELs were 50 mg/kg.
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From page 81...
... In both generations, there was a dose-related increase in the occurrence of buphthalmos (enlargement of the eye) and papillary membrane (a mesodermal layer attached to the iris during embryonic development)
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From page 82...
... No effects were noted in the permethrin-exposed animals. OTHER STUDIES Since the multigenerational studies did not include data on specific reproductive toxicity, such as organ weights, histopathology, or semen measurements, other data were reviewed to determine whether there
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From page 83...
... Another chronic toxicity study submitted to EPA by Wellcome (Life Science Research, 1980) was a dietary feeding study in which Charles River Wistar rats were fed permethrin at 0, 10, 50 and 250 mg/kg of body weight per day (cis/trans ratio, 25:75~.
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From page 84...
... No data are available from dermal exposure studies, but oral dosing would be expected to maximize any effects, since dermal absorption is poor. Where toxic effects have been reported, other similar studies have not confirmed those effects.
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From page 85...
... Current procedures include Bouin's fixation of testes to obtain good histological results. One chronic toxicity study in mice (Tierney
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From page 86...
... , the possibility of male reproductive effects or other reproductive and development effects occurring from wearing permethrin-~mpregnated BDUs or working with treated fabric seems remote. It should be noted, however, that no data are available from dermal exposure studies.
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Key Terms

  • chronic toxicity
  • developmental toxicity
  • testis weight
  • male reproductive
  • reproductive effects

  • dermal exposure
  • toxicity study
  • administered permethrin
  • fed permethrin
  • body weight

  • formalin fixation
  • exposure studies
  • life science
  • persistent papillary
  • reported maternal

  • reproductive function
  • histopathological examinations
  • corn oil
  • reproductive toxicity
  • testicular hypoplasia

  • papillary membrane
  • garment workers
  • increased mortality
  • wistar rats
  • histopathological examination

  • organ weights
  • oral studies
  • effects occurring
  • twenty males
  • characterization document


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