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Health Effects of Permethrin-Impregnated Army Battle-Dress Uniforms (1994) / Chapter Skim
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10 GENOTOXICITY OF PERMETHRIN
Pages 87-92

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From page 87...
... The study did not reveal any mutagenic effect (Shirasu et al., 1979~. In another host-mediated assay employing a similar test system, trans-permethrin at 600 and 3,000 mg/kg of body weight and cis-permethrin at 21 and 54 mg/kg of body weight gave negative results (Miyamoto, 1976~.
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From page 88...
... melanogaster males were administered permethrin in a feeding solution at 5 ppm for 3 days before mating with untreated mus-302 DNA-repair defective females.
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From page 89...
... Small increases in the SCE frequencies were found that were statistically significant, but they might not be biologically meaningful since there was no dose-effect relationship and the increase in SCEs was not always reproducible. Permethrin increased the occurrence of micronuclei over controls when it was assayed at concentrations of 10-100 ,ug/mL in the absence of S9 mix.
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From page 90...
... However, in the presence of S9 mix and permethrin concentrations of 0, 25, 50, 75, 100, or 200 ,ug/mE, the increase in number of micronuclei, observed in some cases, was not statistically significant. The authors concluded that "a definitive conclusion on the genotoxicity of the pyrethroid insecticide can only be possible when more experimental tests are available." Barrueco et al.
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From page 91...
... cold pot A assay, the Bacilus subtilis rec assay, the S cerevisiae D3 mitotic recombination assay, and the unscheduled DNA synthesis in human lung fibroblasts (Garrett et al., 1986~.
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From page 92...
... Three in vitro studies in which clastogenicity of permethrin was investigated provided evidence of potential ciastogenicity of permethrin. Small, statistically significant elevations in sister chomatid exchanges, micronuclei, and chromosomal aberrations in human lymphocyte cultures were reported.
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Key Terms

  • metabolic activation
  • administered permethrin
  • dominant lethal
  • human donors
  • human lymphocyte

  • tested permethrin
  • cultured human
  • unscheduled dna
  • lymphocyte cultures
  • dna synthesis

  • human lymphocytes
  • chinese hamster
  • clastogenic effects
  • rat hepatocytes
  • gene mutations

  • dna damage
  • ratio unknown
  • cho cells
  • concentrations ranging
  • lethal effect

  • five daily
  • mutation assay
  • additional studies
  • purity unknown
  • produce gene

  • hamster ovary
  • daily doses
  • vitro studies
  • mitotic recombination
  • human lung


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