Health Effects of Permethrin-Impregnated Army Battle-Dress Uniforms (1994) / Chapter Skim
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11 CARCINOGENICITY OF PERMETHRIN
11 CARCINOGENICITY OF PERMETHRIN
Pages 93-106
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From page 93... ...
CARCINOGENICITY STUDIES IN MICE Four mouse carcinogenicity studies have been conducted with permethrin; in all four studies, permethrin was administered to mice in their diet. ICI Mouse Study Hart and co-workers (1977)
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From page 94... ...
A slight increase was reported in lung adenomas in Inales at the highest dose tested (2,500 ppm) , which was not statistically significant.
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There was a statistically significant increase in mortality in male and female mice at the highest dose (4,000 ppm)
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From page 96... ...
· Highly statistically significant increases in liver adenomas in female mice at mid and high doses (both were outside historical control range) and a significant dose-related trend; statistically significant increases in combined liver adenomas and carcinomas at mid and high doses and a significant dose-related trend.
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From page 98... ...
bHistorical control data (mean and percentage range) derived from nine studies containing 807 female CFLP control mice and mice affected with lung adenomas and carcinomas.
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From page 99... ...
Two independent evaluations of the histopathological data from this study concluded that there was no carcinogenic potential for permethrin. Although there was a dose-dependent increase in gross liver weight in both males and females, those values were small and not statistically significant.
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From page 100... ...
was not statistically significant either. In their analysis of the data, EPA adjusted the incidence by the amount of lung tissue examined.
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From page 101... ...
TUMOR PROMOTION STUDIES: SHIMKIN MOUSE LUNG BIOASSAY Groups of 16 male and 16 female strain A/J mice were given permethrin at 0, 285, 475 (females only) , 713.5, or 1,425 mg/kg (cis/trans ratio, 40:60)
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From page 102... ...
increases in lung adenomas and carcinomas combined were observed at the mid and high doses, along with a statistically significant (p < 0.01) dose-related trend.
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From page 103... ...
CEPA calculated a human oncogenic potency factor of only 0.011 (mg/kg/day)
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~i, is based on the oral administered dose rather than the internal absorbed dose. To use this potency factor in conjunction with the calculated human internal dose resulting from dermal exposure, it should be adjusted upward by an oral absorption factor for the experimental animals.
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From page 105... ...
Conclusions An upper bound on the lifetime carcinogenic risk to military personnel wearing permethrin-impregnated uniforms is estimated to be I.6 x lo-6. That value applies to non-field and field personnel, assuming that topically applied DEET does not enhance dermal absorption of permethrin.
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From page 106... ...
However, if it is possible to have two sets of uniforms, treated and untreated, then it is recommended that only uniforms worn by field personnel be made from permethrin-impregnated fabric. The estimated upper-bound lifetime carcinogenic risk to garment workers, 6.9 x 10~7, iS less than half the calculated upper-bound risk to military personnel.
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