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Vitamin Tolerance of Animals (1987) / Chapter Skim
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3 Vitamin E
Pages 23-30

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From page 23...
... NUTRITIONAL ROLE Dietary Requirements of Various Species After vitamin E was recognized as an essential nutrient, numerous interrelationships were identified between it and other dietary factors, such as selenium and synthetic antioxidants, in preventing many varied animal diseases. (See reviews by Mason and Horwitt, 1972; Scott, 1978; Combs, 1981; Machlin, 1980, 1984.)
From page 24...
... Lipid peroxidation initiated within the membrane is not presumed to be affected by the selenium-dependent glutathione peroxidase, which is present only in the cytosol and mitochondrial matrix space. Lesions of this nature are thought to result in the deficiency syndromes described above that respond only to vitamin E or to fat-soluble synthetic antioxidants capable of entering membranes.
From page 25...
... The species have twice these levels in the liver and heart but only half the levels in the skeletal muscle. Although tocopherol is associated with the lipid phase of cells, tissue tocopherol concentrations do not relate directly to tissue lipid levels.
From page 26...
... 26 to ._ ¢ ·_4 ._ 4= ._ o CQ as ._ o In · _ ·_4 Lo c: as co Pa Do Lo P; a o U)
From page 28...
... This level of the vitamin significantly reduced the relative weight of the adrenal gland but did not affect the relative weights of liver, kidney, spleen, or testes. Although the total protein concentration of plasma was not significantly affected, the high level of vitamin E increased albumin concentrations and decreased globulin concentrations.
From page 29...
... Their results showed that vitamin E treatment did not significantly affect subjective evaluations of work performance, sexuality, general well-being, muscular weakness, or gastrointestinal disturbances. It also did not affect prothrombin times, total blood leukocyte counts, or serum creatine phosphokinase activities.
From page 30...
... 1977b. Effect of high levels of dietary vitamin E on liver and plasma lipids and fat soluble vitamins in rats.


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