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Vitamin Tolerance of Animals (1987) / Chapter Skim
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1 Vitamin A
Pages 3-10

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From page 3...
... , nonhuman primates (National Research Council, 1978d) , and some warmwater fishes (National Research Council, 1983)
From page 4...
... The molecular bases for the roles of vitamin A in growth, reproduction, and epithelial health have been studied extensively but remain incompletely understood. The most widely accepted hypotheses propose a role in synthesis of glycoproteins that may control cell differentiation and involvement in the control of gene expression (Olson, 1984~.
From page 5...
... HYPERVITAMINOSIS A voluminous amount of literature clearly indicates that vitamin A has the potential to act as a cumulative toxicant in most species that have been studied (Nieman and Obbink, 1954; Moore, 1957; Hayes and Hegsted, 1973; Bauernfeind, 1980; Agricultural Research Council, 19~() , 1981; Ong and Chytil, 1983; Olson, 1984~.
From page 7...
... 7 - - ~ ~ ; it, _~ 9 ' ' ~' ' ~- _, j ~ ~ ~ ~ ~ ~ ~ ~ ,' 3, D _ Y ~In ~A ~ a ~ ~a ~4 4-,~ ~is _ Hi ~_ _ ~Ct hi _ ~ _ _ ._ ~ ~ ~ ~ 0 0 0 0 0 oo 0 oo oo 0 Hi: ~= ~ ~ 3 ~`= ~ ~ Cal Us~ ~Cal A)
From page 8...
... Consequently, the presumed upper safe levels for orally administered vitamin A are necessarily estimates. The presumed upper safe levels summarized in Table 3 represent levels between the minimal requirements recommended by the National Research Council (NRC)
From page 9...
... Washington, D.C.: National Academy Press. National Research Council.
From page 10...
... National Research Council.


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