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Vitamin Tolerance of Animals (1987) / Chapter Skim
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4 Vitamin K
Pages 31-35

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From page 31...
... NUTRITIONAL ROLE Dietary Requirements of Various Species Dietary adequacy of vitamin K is often defined as the amount of vitamin needed to maintain normal levels of plasma vitamin K-dependent clotting factors. It has been difficult to demonstrate clearly and to measure dietary vitamin K requirements for many species.
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From page 32...
... They found that fecal excretion of the unmetabolized form following a 1-mg dose of phylloquinone was less than 20 percent in normal subjects but increased to more than 70 percent in patients with impaired fat absorption. Animal diets could contain menadione, a mixture of menaquinones and phylloquinone, and there is evidence that the absorption of these various forms of vitamin K differs significantly.
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From page 33...
... The major route of excretion of intravenously administered radioactive phylloquinone appears to be fecal, with only a small percentage of fecal radioactivity present as unmetabolized phylloquinone. The metabolism of radioactive phylloquinone has now been studied in both the rat and in humans, and the glycones of the 5- and 7-carbon side chain carboxylic acid derivatives appear to be major excretion products.
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From page 34...
... _ ~ ~ ,- ~ ° ° ~ ~ ~ ~o ~ ~o ~i ~ o o ~o ~ ~ ° ~o CD ~ Z ~¢¢ CO ~ ~ ~ ~ ~ Z Z ~Z ¢ ~ ~Z i ~ ~ ~ C ~i~ ~ i~ a~ ~ ~ ~ ~ ~ a' cn u~ u~ co u~ co ~co cn cn u~ co cn u~ u ~cn u~ co o: ~ ~ ~ u ~ 0 0 0 0 0 0 ,[ ~0 0 0 0 0 0 0 0 0 0 0 0 _ _ _ 0 _ eo CO ~CO ¢U ~ au a~ a ~a~ ~ ~ ~ a~ b~ ~ ~ b4 bO ~bC ~ to ~ b0 bC ?
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From page 35...
... 1971. Vitamin K supplementation for infants receiving milk substitute infant formulas and for those with fat malabsorption.
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Key Terms

  • clotting factors
  • dietary requirements
  • called vitamin
  • laboratory animals
  • menadione bisulfite

  • menadione sodium
  • dietary vitamin
  • menadione forms
  • radioactive phylloquinone
  • parenteral administration

  • limited amount
  • called menadione
  • hemolytic anemia
  • compound called
  • synthesized vitamins

  • salt called
  • bisulfite addition
  • prevent hemorrhagic
  • intravenously administered
  • menadione metabolism

  • dietary deficiency
  • spontaneous deficiency
  • diphosphate localizes
  • massive doses
  • chain carboxylic

  • times dietary
  • develop dietary
  • parent compound
  • major route
  • originally isolated


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