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Vitamin Tolerance of Animals (1987) / Chapter Skim
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6 Thiamin
Pages 43-46

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From page 43...
... Biochemical Functions The enzyme thiamin pyrophosphokinase and adenosine triphosphate (ATP) convert thiamin into its metabolically active coenzyme form, thiamin pyrophosphate (TPP)
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From page 44...
... There is virtually no information available to indicate any cumulative effects of thiamin administered chronically at levels below those that are acutely toxic. In acute toxicity studies, excess thiamin appears to block nerve transmission, producing curare-like signs in the treated animal (Haley and Flesher, 1946; Smith et al., 1947, 1948; Haley, 1948; Hayashi et al., 1965~.
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From page 45...
... PRESUMED UPPER SAFE LEVELS The maximum tolerable level of thiamin administered by either oral or parenteral routes has yet to be determined in most domestic animal species. In dogs, 100 to 115,ug of thiamin/kg of BW/day (oral route, Noel et al., 1977)
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From page 46...
... 1977. Effects of thiamine administration on blood lactic acid concentration and mineral metabolism in sheep.
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Key Terms

  • thiamin toxicity
  • laboratory animals
  • thiamine requirement
  • nerve transmission
  • animal species

  • acute toxicity
  • acutely toxic
  • thiamin status
  • excess thiamin
  • thiamin deficiency

  • requirement level
  • thiamin administered
  • absorption mechanism
  • domestic animal
  • dietary intakes

  • intravenous administration
  • block nerve
  • toxic levels
  • apparently safe
  • thiamin requirements

  • thiamin excess
  • domestic animals
  • thiamin appears
  • von thiamin
  • glucose metabolism

  • diagnose und
  • thiamin mononitrate
  • growing germfree
  • animal feeds
  • vitamin parenterally


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