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Vitamin Tolerance of Animals (1987) / Chapter Skim
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8 Riboflavin (Vitamin B2)
Pages 53-57

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From page 53...
... Chronic riboflavin deficiency can be fatal. Specific signs of riboflavin deficiency include seborrheic dermatitis, cheilosis, conjunctivitis, and congenital malformations in rats and mice; curled toe paralysis, reduced embryonic survival, and dermatitis in poultry; muscular weakness, ataxia, dermatitis, anemia, and cardiological changes in dogs and foxes; dermatitis, alopecia, ataxia, corneal degeneration, hemmorhagic adrenals, and fatty degeneration of the kidneys in pigs; and dermatitis and normocytic hypochromic anemia in primates (Nutrition Foundation, 1984~.
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From page 54...
... CH2 OH HO HO HO-H -H -H CH2 H 3 C ~ N ~ N ~ O H3C~ O OH OH OH 1 ~ ~I! CH2-C C-C CH2 O-P - OH 1 1 1 1 1 CH3~N N'C-O FMN l ~ ~ CH3-~ N ~ C ~ NH 1 FAD ABSORPTION AND METABOLISM o 11 o OH OH OH CH2 C C- C CH2 1 1 1 1 1 I H H H O CH3 - :' C=0 0 P OH CH3-IN C,NH 11 o o O-P OH NH2 CH2 AN ~0~ FIGURE 12 Chemical structures of riboflavin and its coenzyme forms.
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From page 55...
... fed diets containing l, 2, 4 or 6 mg riboflavin/kg to gestating rats and reported larger litter sizes at levels greater than l mg/kg. No effects on progeny whole body riboflavin pool or on dam BW, liver riboflavin concentration, or weight gain were noted.
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From page 57...
... results in a plateauing of the tissue contents of the vitamin in rats. Other available data with this species suggest that dietary levels between 10 and 20 times the requirement (possibly 100 times)
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Key Terms

  • fed diets
  • riboflavin deficiency
  • sodium riboflavinate
  • oral doses
  • successive generations

  • level exceeding
  • riboflavinate administered
  • tolerated oral
  • electron transport
  • weanling rats

  • acid oxidase
  • riboflavin coenzymes
  • coenzyme forms
  • tolerated safely
  • dietary requirement

  • tissue contents
  • liver riboflavin
  • acylcoa dehydrogenases
  • responds directly
  • muscular weakness

  • congenital malformations
  • mitochondrial electron
  • slightly improved
  • riboflavin status
  • rumen microflora

  • studied riboflavin
  • glucose oxidase
  • orally administered
  • following administration
  • cytochrome reductase


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